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Xist RNA antagonizes the SWI/SNF chromatin remodeler BRG1 on the inactive X chromosome
The noncoding RNA Xist recruits silencing factors to the inactive X chromosome (Xi) and facilitates re-organization of Xi structure. Here, we examine the mouse epigenomic landscape of Xi and assess how Xist alters chromatin accessibility. Interestingly, Xist deletion triggers a gain of accessibility...
Autores principales: | Jégu, Teddy, Blum, Roy, Cochrane, Jesse C., Yang, Lin, Wang, Chen-Yu, Gilles, Maud-Emmanuelle, Colognori, David, Szanto, Attila, Marr, Sharon K., Kingston, Robert E., Lee, Jeannie T. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421574/ https://www.ncbi.nlm.nih.gov/pubmed/30664740 http://dx.doi.org/10.1038/s41594-018-0176-8 |
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