Cargando…

Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice

Recent evidences suggest the involvement of DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1 A) in Alzheimer’s disease (AD). Here we showed that DYRK1A undergoes a proteolytic processing in AD patients hippocampus without consequences on its kinase activity. Resulting truncated f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Souchet, Benoît, Audrain, Mickael, Billard, Jean Marie, Dairou, Julien, Fol, Romain, Orefice, Nicola Salvatore, Tada, Satoru, Gu, Yuchen, Dufayet-Chaffaud, Gaelle, Limanton, Emmanuelle, Carreaux, François, Bazureau, Jean-Pierre, Alves, Sandro, Meijer, Laurent, Janel, Nathalie, Braudeau, Jérôme, Cartier, Nathalie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421685/ https://www.ncbi.nlm.nih.gov/pubmed/30885273 http://dx.doi.org/10.1186/s40478-019-0678-6

Ejemplares similares

Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression
por: Audrain, Mickael, et al.
Publicado: (2016)

Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A
por: Nguyen, Thu Lan, et al.
Publicado: (2018)

Design and Microwave Synthesis of New (5Z) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5Z) 2-Amino-5-arylidene-1,3-thiazol-4(5H)-one as New Inhibitors of Protein Kinase DYRK1A
por: Bourahla, Khadidja, et al.
Publicado: (2021)

Is it time to rethink the Alzheimer's disease drug development strategy by targeting its silent phase?
por: Souchet, Benoit, et al.
Publicado: (2018)

Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases
por: Loaëc, Nadège, et al.
Publicado: (2017)

Molecular Rescue of Dyrk1A Overexpression Alterations in Mice with Fontup(®) Dietary Supplement: Role of Green Tea Catechins
por: Gu, Yuchen, et al.
Publicado: (2020)

Real-Time Monitoring of Exosome Enveloped-AAV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain
por: Orefice, Nicola Salvatore, et al.
Publicado: (2019)

Genetically modified macrophages accelerate myelin repair
por: Aigrot, Marie‐Stéphane, et al.
Publicado: (2022)

One-carbon cycle alterations induced by Dyrk1a dosage
por: Delabar, Jean-Maurice, et al.
Publicado: (2014)

A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives
por: Bourahla, Khadidja, et al.
Publicado: (2011)

Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models
por: Souchet, Benoit, et al.
Publicado: (2019)

Adeno-Associated Virus-Based Gene Therapy for CNS Diseases
por: Hocquemiller, Michaël, et al.
Publicado: (2016)

Corrective effects of hepatotoxicity by hepatic Dyrk1a gene delivery in mice with intermediate hyperhomocysteinemia
por: Latour, Alizée, et al.
Publicado: (2015)

Catechins as a Potential Dietary Supplementation in Prevention of Comorbidities Linked with Down Syndrome
por: Noll, Christophe, et al.
Publicado: (2022)

DYRK1A Overexpression in Mice Downregulates the Gonadotropic Axis and Disturbs Early Stages of Spermatogenesis
por: Dard, Rodolphe, et al.
Publicado: (2021)

Over‐expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice
por: Postic, Guillaume, et al.
Publicado: (2023)

DYRK1A inhibition and cognitive rescue in a Down syndrome mouse model are induced by new fluoro-DANDY derivatives
por: Neumann, Fernanda, et al.
Publicado: (2018)

Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions
por: Brun, Elodie, et al.
Publicado: (2015)

DYRK1A, a Novel Determinant of the Methionine-Homocysteine Cycle in Different Mouse Models Overexpressing this Down-Syndrome-Associated Kinase
por: Noll, Christophe, et al.
Publicado: (2009)

Cadmium Alters the Biotransformation of Carcinogenic Aromatic Amines by Arylamine N-Acetyltransferase Xenobiotic-Metabolizing Enzymes: Molecular, Cellular, and in Vivo Studies
por: Ragunathan, Nilusha, et al.
Publicado: (2010)

DYRK1A and Activity-Dependent Neuroprotective Protein Comparative Diagnosis Interest in Cerebrospinal Fluid and Plasma in the Context of Alzheimer-Related Cognitive Impairment in Down Syndrome Patients
por: Moreau, Manon, et al.
Publicado: (2022)

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models
por: Souchet, Benoit, et al.
Publicado: (2015)

Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A
por: Widowati, Esti Wahyu, et al.
Publicado: (2018)

Plasma DYRK1A as a novel risk factor for Alzheimer's disease
por: Janel, N, et al.
Publicado: (2014)

DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B
por: Yousefelahiyeh, Mina, et al.
Publicado: (2018)

Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B
por: Papenfuss, Marco, et al.
Publicado: (2022)

[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors
por: Lechner, Christian, et al.
Publicado: (2019)

El cacao
por: Braudeau, Jean
Publicado: (1970)

Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer’s disease
por: Janel, N, et al.
Publicado: (2017)

Emerging roles of DYRK2 in cancer
por: Tandon, Vasudha, et al.
Publicado: (2021)

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design
por: Meine, Rosanna, et al.
Publicado: (2018)

Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview
por: Lindberg, Mattias F., et al.
Publicado: (2021)

Dual inhibition of HSF1 and DYRK2 impedes cancer progression
por: Tandon, Vasudha, et al.
Publicado: (2023)

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A
por: Guedj, Fayçal, et al.
Publicado: (2009)

The Omnipresence of DYRK1A in Human Diseases
por: Deboever, Estelle, et al.
Publicado: (2022)

Proteolysis in Helicobacter pylori-Induced Gastric Cancer
por: Posselt, Gernot, et al.
Publicado: (2017)

Hypothesis and Theory: Circulating Alzheimer's-Related Biomarkers in Type 2 Diabetes. Insight From the Goto-Kakizaki Rat
por: Movassat, Jamileh, et al.
Publicado: (2019)

Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases
por: Myrianthopoulos, Vassilios, et al.
Publicado: (2012)

Natural Aristolactams and Aporphine Alkaloids as Inhibitors of CDK1/Cyclin B and DYRK1A
por: Marti, Guillaume, et al.
Publicado: (2013)

CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
por: Lan, Bin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fr97r1bd7dkolct716p49c586i