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Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system

OBJECTIVE: To generate novel rabbit models with a large-fragment deletion of either LDL receptor (LDLR) and/or apolipoprotein (apoE) genes for the study of hyperlipidemic and atherosclerosis. METHODS: CRISPR/Cas9 system directed by a multiple sgRNAs system was used in rabbit embryos to edit their LD...

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Detalles Bibliográficos
Autores principales:	Yuan, Tingting, Zhong, Yi, Wang, Yingge, Zhang, Ting, Lu, Rui, Zhou, Minya, Lu, Yaoyao, Yan, Kunning, Chen, Yajie, Hu, Zhehui, Liang, Jingyan, Fan, Jianglin, Cheng, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421715/ https://www.ncbi.nlm.nih.gov/pubmed/30885208 http://dx.doi.org/10.1186/s12944-019-1013-8

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