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The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer
Cervical cancer is one of the most common malignant neoplasms in gynecology. Protein tyrosine kinase 7 (PTK7) with an inactive kinase domain is an important regulator of multiple Wnt pathways under normal and various pathological conditions and overexpressed in various tumors; however, the clinical...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421733/ https://www.ncbi.nlm.nih.gov/pubmed/30944666 http://dx.doi.org/10.1155/2019/5380197 |
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author | Sun, Jun-Jie Li, Hong-Lin Guo, Su-Jie Ma, Hui Liu, Shen-Jia Liu, Dong Xue, Feng-Xia |
author_facet | Sun, Jun-Jie Li, Hong-Lin Guo, Su-Jie Ma, Hui Liu, Shen-Jia Liu, Dong Xue, Feng-Xia |
author_sort | Sun, Jun-Jie |
collection | PubMed |
description | Cervical cancer is one of the most common malignant neoplasms in gynecology. Protein tyrosine kinase 7 (PTK7) with an inactive kinase domain is an important regulator of multiple Wnt pathways under normal and various pathological conditions and overexpressed in various tumors; however, the clinical and biological significance of PTK7 in cervical cancer is still unknown. In the present study, the protein expression level of PTK7 was detected in clinical cervical cancer patient samples, and the relationship between PTK7 expression and clinicopathological features was analyzed. In addition, the Kaplan-Meier method was performed to estimate the overall survival (OS) and progression-free survival (PFS) of patients to investigate the clinicopathological significance of PTK7 expression. Functional assays demonstrated that knocking down PTK7 might inhibit the ability of cancer cells to proliferate and invade or migrate, both in vivo and in vitro. Thus, PTK7 might serve as a potential target for cervical cancer. |
format | Online Article Text |
id | pubmed-6421733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64217332019-04-03 The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer Sun, Jun-Jie Li, Hong-Lin Guo, Su-Jie Ma, Hui Liu, Shen-Jia Liu, Dong Xue, Feng-Xia Dis Markers Research Article Cervical cancer is one of the most common malignant neoplasms in gynecology. Protein tyrosine kinase 7 (PTK7) with an inactive kinase domain is an important regulator of multiple Wnt pathways under normal and various pathological conditions and overexpressed in various tumors; however, the clinical and biological significance of PTK7 in cervical cancer is still unknown. In the present study, the protein expression level of PTK7 was detected in clinical cervical cancer patient samples, and the relationship between PTK7 expression and clinicopathological features was analyzed. In addition, the Kaplan-Meier method was performed to estimate the overall survival (OS) and progression-free survival (PFS) of patients to investigate the clinicopathological significance of PTK7 expression. Functional assays demonstrated that knocking down PTK7 might inhibit the ability of cancer cells to proliferate and invade or migrate, both in vivo and in vitro. Thus, PTK7 might serve as a potential target for cervical cancer. Hindawi 2019-03-03 /pmc/articles/PMC6421733/ /pubmed/30944666 http://dx.doi.org/10.1155/2019/5380197 Text en Copyright © 2019 Jun-Jie Sun et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sun, Jun-Jie Li, Hong-Lin Guo, Su-Jie Ma, Hui Liu, Shen-Jia Liu, Dong Xue, Feng-Xia The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer |
title | The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer |
title_full | The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer |
title_fullStr | The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer |
title_full_unstemmed | The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer |
title_short | The Increased PTK7 Expression Is a Malignant Factor in Cervical Cancer |
title_sort | increased ptk7 expression is a malignant factor in cervical cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421733/ https://www.ncbi.nlm.nih.gov/pubmed/30944666 http://dx.doi.org/10.1155/2019/5380197 |
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