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Nanomaterial Exposure Induced Neutrophil Extracellular Traps: A New Target in Inflammation and Innate Immunity
Nanotechnology has become a novel subject with impact in many research and technology areas. Nanoparticles (NPs), as a key component in nanotechnology, are widely used in many areas such as optical, magnetic, electrical, and mechanical engineering. The biomedical and pharmaceutical industries have e...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421747/ https://www.ncbi.nlm.nih.gov/pubmed/30944832 http://dx.doi.org/10.1155/2019/3560180 |
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author | Yang, Hang Marion, Tony N. Liu, Yi Zhang, Lingshu Cao, Xue Hu, Huifang Zhao, Yi Herrmann, Martin |
author_facet | Yang, Hang Marion, Tony N. Liu, Yi Zhang, Lingshu Cao, Xue Hu, Huifang Zhao, Yi Herrmann, Martin |
author_sort | Yang, Hang |
collection | PubMed |
description | Nanotechnology has become a novel subject with impact in many research and technology areas. Nanoparticles (NPs), as a key component in nanotechnology, are widely used in many areas such as optical, magnetic, electrical, and mechanical engineering. The biomedical and pharmaceutical industries have embraced NPs as a viable drug delivery modality. As such, the potential for NP-induced cytotoxicity has emerged as a major concern for NP drug delivery systems. Thus, it is important to understand how NPs affect the innate immune system. As the most abundant myeloid cell type in innate immune responses, neutrophils are critical for concerns about potentially toxic side effects of NPs. When activated by innate immune stimuli, neutrophils may initiate NETosis to release neutrophil extracellular traps (NETs). Herein, we have reviewed the relationship between NPs and the induction of NETosis and release of NETs. |
format | Online Article Text |
id | pubmed-6421747 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-64217472019-04-03 Nanomaterial Exposure Induced Neutrophil Extracellular Traps: A New Target in Inflammation and Innate Immunity Yang, Hang Marion, Tony N. Liu, Yi Zhang, Lingshu Cao, Xue Hu, Huifang Zhao, Yi Herrmann, Martin J Immunol Res Review Article Nanotechnology has become a novel subject with impact in many research and technology areas. Nanoparticles (NPs), as a key component in nanotechnology, are widely used in many areas such as optical, magnetic, electrical, and mechanical engineering. The biomedical and pharmaceutical industries have embraced NPs as a viable drug delivery modality. As such, the potential for NP-induced cytotoxicity has emerged as a major concern for NP drug delivery systems. Thus, it is important to understand how NPs affect the innate immune system. As the most abundant myeloid cell type in innate immune responses, neutrophils are critical for concerns about potentially toxic side effects of NPs. When activated by innate immune stimuli, neutrophils may initiate NETosis to release neutrophil extracellular traps (NETs). Herein, we have reviewed the relationship between NPs and the induction of NETosis and release of NETs. Hindawi 2019-02-28 /pmc/articles/PMC6421747/ /pubmed/30944832 http://dx.doi.org/10.1155/2019/3560180 Text en Copyright © 2019 Hang Yang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yang, Hang Marion, Tony N. Liu, Yi Zhang, Lingshu Cao, Xue Hu, Huifang Zhao, Yi Herrmann, Martin Nanomaterial Exposure Induced Neutrophil Extracellular Traps: A New Target in Inflammation and Innate Immunity |
title | Nanomaterial Exposure Induced Neutrophil Extracellular Traps: A New Target in Inflammation and Innate Immunity |
title_full | Nanomaterial Exposure Induced Neutrophil Extracellular Traps: A New Target in Inflammation and Innate Immunity |
title_fullStr | Nanomaterial Exposure Induced Neutrophil Extracellular Traps: A New Target in Inflammation and Innate Immunity |
title_full_unstemmed | Nanomaterial Exposure Induced Neutrophil Extracellular Traps: A New Target in Inflammation and Innate Immunity |
title_short | Nanomaterial Exposure Induced Neutrophil Extracellular Traps: A New Target in Inflammation and Innate Immunity |
title_sort | nanomaterial exposure induced neutrophil extracellular traps: a new target in inflammation and innate immunity |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421747/ https://www.ncbi.nlm.nih.gov/pubmed/30944832 http://dx.doi.org/10.1155/2019/3560180 |
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