Biological Safety Studies and Simultaneous Determination of Linagliptin and Synthetic Impurities by LC-PDA

A stability-indicating LC method was developed for quantification of linagliptin (LGT) and three synthetic impurities. The method utilizes a Thermo Scientific® RP-8 column (100 mm × 4.6 mm; 5 μm) with the PDA detector for quantitation of impurities. A mixture of 0.1% formic acid with pH 3.5 (A) and...

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Detalles Bibliográficos
Autores principales: Heleno Ferreira, Raquel Balestri, Duarte, Jonathaline Apollo, Ferreira, Flávio Dias, de Oliveira, Luis Flávio Souza, Machado, Michel Mansur, Malesuik, Marcelo Donadel, Paula, Fávero Reisdorfer, Steppe, Martin, Schapoval, Elfrides Eva Shermann, Paim, Clésio Soldateli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421826/
https://www.ncbi.nlm.nih.gov/pubmed/30944754
http://dx.doi.org/10.1155/2019/7534609

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