Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes

The presence of supernumerary centrosomes is prevalent in cancer, where they promote the formation of transient multipolar mitotic spindles. Active clustering of supernumerary centrosomes enables the formation of a functional bipolar spindle that is competent to complete a bipolar division. Disrupti...

Descripción completa

Detalles Bibliográficos
Autores principales: Navarro-Serer, Bernat, Childers, Eva P., Hermance, Nicole M., Mercadante, Dayna, Manning, Amity L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422193/
https://www.ncbi.nlm.nih.gov/pubmed/30899434
http://dx.doi.org/10.18632/oncotarget.26714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422193/
https://www.ncbi.nlm.nih.gov/pubmed/30899434
http://dx.doi.org/10.18632/oncotarget.26714

Ejemplares similares