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Differential localizations of protein phosphatase 1 isoforms determine their physiological function in the heart

Protein phosphatase 1 isoforms α, β, and γ (PP1α, PP1β, and PP1γ) are highly homologous in the catalytic domains but have distinct subcellular localizations. In this study, we utilized both primary cell culture and knockout mice to investigate the isoform-specific roles of PP1s in the heart. In both...

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Detalles Bibliográficos
Autores principales: Liu, Ruijie, Miller, Christian, D’Annibale, Christiana, Vo, Kimberly, Jacobs, Ashley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422231/
https://www.ncbi.nlm.nih.gov/pubmed/30721967
http://dx.doi.org/10.1093/abbs/gmy171