RNAi-based small molecule repositioning reveals clinically approved urea-based kinase inhibitors as broadly active antivirals

Influenza viruses (IVs) tend to rapidly develop resistance to virus-directed vaccines and common antivirals targeting pathogen determinants, but novel host-directed approaches might preclude resistance development. To identify the most promising cellular targets for a host-directed approach against...

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Detalles Bibliográficos
Autores principales: Lesch, Markus, Luckner, Madlen, Meyer, Michael, Weege, Friderike, Gravenstein, Isabella, Raftery, Martin, Sieben, Christian, Martin-Sancho, Laura, Imai-Matsushima, Aki, Welke, Robert-William, Frise, Rebecca, Barclay, Wendy, Schönrich, Günther, Herrmann, Andreas, Meyer, Thomas F., Karlas, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422253/
https://www.ncbi.nlm.nih.gov/pubmed/30883607
http://dx.doi.org/10.1371/journal.ppat.1007601

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