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Interspecies comparison of putative ligand binding sites of human, rat and mouse P-glycoprotein
Prior to the clinical phases of testing, safety, efficacy and pharmacokinetic profiles of lead compounds are evaluated in animal studies. These tests are primarily performed in rodents, such as mouse and rats. In order to reduce the number of animal experiments, computational models that predict the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422297/ https://www.ncbi.nlm.nih.gov/pubmed/29936088 http://dx.doi.org/10.1016/j.ejps.2018.06.022 |