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Prediction of drug–ABC-transporter interaction — Recent advances and future challenges☆
With the discovery of P-glycoprotein (P-gp), it became evident that ABC-transporters play a vital role in bioavailability and toxicity of drugs. They prevent intracellular accumulation of toxic compounds, which renders them a major defense mechanism against xenotoxic compounds. Their expression in c...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422311/ https://www.ncbi.nlm.nih.gov/pubmed/25769815 http://dx.doi.org/10.1016/j.addr.2015.03.001 |