Immune evasion by TGFβ-induced miR-183 repression of MICA/B expression in human lung tumor cells

Immune escape is a hallmark of cancer. In human lung cancer, we have identified a unique microRNA (miR)-based pathway employed by tumor cells to repress detection by immune cells via the NKG2D-MICA/B receptor-ligand system. MICA/B is readily induced by cell transformation and serves as a danger sign...

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Detalles Bibliográficos
Autores principales: Trinh, Thu Le, Kandell, Wendy M., Donatelli, Sarah S., Tu, Nhan, Tejera, Melba M., Gilvary, Danielle L., Eksioglu, Erika A., Burnette, Alexis, Adams, William A., Liu, Jinhong, Teer, Jamie K., Djeu, Julie Y., Coppola, Domenico, Wei, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422376/
https://www.ncbi.nlm.nih.gov/pubmed/30906652
http://dx.doi.org/10.1080/2162402X.2018.1557372

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