CD8(+) cytotoxic T cell responses to dominant tumor-associated antigens are profoundly weakened by aging yet subdominant responses retain functionality and expand in response to chemotherapy

Increasing life expectancy is associated with increased cancer incidence, yet the effect of cancer and anti-cancer treatment on elderly patients and their immune systems is not well understood. Declining T cell function with aging in response to infection and vaccination is well documented, however...

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Detalles Bibliográficos
Autores principales: Jackaman, Connie, Gardner, Joanne K., Tomay, Federica, Spowart, Joshua, Crabb, Hannah, Dye, Danielle E., Fox, Simon, Proksch, Stephen, Metharom, Pat, Dhaliwal, Satvinder S., Nelson, Delia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422383/
https://www.ncbi.nlm.nih.gov/pubmed/30906657
http://dx.doi.org/10.1080/2162402X.2018.1564452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422383/
https://www.ncbi.nlm.nih.gov/pubmed/30906657
http://dx.doi.org/10.1080/2162402X.2018.1564452

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