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CD8(+) cytotoxic T cell responses to dominant tumor-associated antigens are profoundly weakened by aging yet subdominant responses retain functionality and expand in response to chemotherapy
Increasing life expectancy is associated with increased cancer incidence, yet the effect of cancer and anti-cancer treatment on elderly patients and their immune systems is not well understood. Declining T cell function with aging in response to infection and vaccination is well documented, however...
Autores principales: | Jackaman, Connie, Gardner, Joanne K., Tomay, Federica, Spowart, Joshua, Crabb, Hannah, Dye, Danielle E., Fox, Simon, Proksch, Stephen, Metharom, Pat, Dhaliwal, Satvinder S., Nelson, Delia J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422383/ https://www.ncbi.nlm.nih.gov/pubmed/30906657 http://dx.doi.org/10.1080/2162402X.2018.1564452 |
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