The SNAP-25 linker supports fusion intermediates by local lipid interactions

SNAP-25 is an essential component of SNARE complexes driving fast Ca(2+)-dependent exocytosis. Yet, the functional implications of the tandem-like structure of SNAP-25 are unclear. Here, we have investigated the mechanistic role of the acylated “linker” domain that concatenates the two SNARE motifs...

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Detalles Bibliográficos
Autores principales: Shaaban, Ahmed, Dhara, Madhurima, Frisch, Walentina, Harb, Ali, Shaib, Ali H, Becherer, Ute, Bruns, Dieter, Mohrmann, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422494/
https://www.ncbi.nlm.nih.gov/pubmed/30883328
http://dx.doi.org/10.7554/eLife.41720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422494/
https://www.ncbi.nlm.nih.gov/pubmed/30883328
http://dx.doi.org/10.7554/eLife.41720

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