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Meningococcal disease in adolescents and young adults: a review of the rationale for prevention through vaccination

Invasive meningococcal disease (IMD) caused by Neisseria meningitidis is characterized by high mortality and morbidity. While IMD incidence peaks in both infants and adolescents/young adults, carriage rates are often highest in the latter age groups, increasing IMD risk and the likelihood of transmi...

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Autores principales: Burman, Cynthia, Serra, Lidia, Nuttens, Charles, Presa, Jessica, Balmer, Paul, York, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422514/
https://www.ncbi.nlm.nih.gov/pubmed/30273506
http://dx.doi.org/10.1080/21645515.2018.1528831
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author Burman, Cynthia
Serra, Lidia
Nuttens, Charles
Presa, Jessica
Balmer, Paul
York, Laura
author_facet Burman, Cynthia
Serra, Lidia
Nuttens, Charles
Presa, Jessica
Balmer, Paul
York, Laura
author_sort Burman, Cynthia
collection PubMed
description Invasive meningococcal disease (IMD) caused by Neisseria meningitidis is characterized by high mortality and morbidity. While IMD incidence peaks in both infants and adolescents/young adults, carriage rates are often highest in the latter age groups, increasing IMD risk and the likelihood of transmission. Effective vaccines are available for 5 of 6 disease-causing serogroups. Because adolescents/young adults represent a significant proportion of cases, often have the highest carriage rate, and have characteristically low vaccination adherence, efforts should be focused on educating this population regarding long-term consequences of infection and the importance of meningococcal vaccination in prevention. This review describes the role of adolescents/young adults in meningococcal transmission and the clinical consequences and characteristics of IMD in this population. With a focus on countries with advanced economies that have specific meningococcal vaccination recommendations, the epidemiology of meningococcal disease and vaccination recommendations in adolescents/young adults will also be discussed.
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spelling pubmed-64225142019-03-22 Meningococcal disease in adolescents and young adults: a review of the rationale for prevention through vaccination Burman, Cynthia Serra, Lidia Nuttens, Charles Presa, Jessica Balmer, Paul York, Laura Hum Vaccin Immunother Review Invasive meningococcal disease (IMD) caused by Neisseria meningitidis is characterized by high mortality and morbidity. While IMD incidence peaks in both infants and adolescents/young adults, carriage rates are often highest in the latter age groups, increasing IMD risk and the likelihood of transmission. Effective vaccines are available for 5 of 6 disease-causing serogroups. Because adolescents/young adults represent a significant proportion of cases, often have the highest carriage rate, and have characteristically low vaccination adherence, efforts should be focused on educating this population regarding long-term consequences of infection and the importance of meningococcal vaccination in prevention. This review describes the role of adolescents/young adults in meningococcal transmission and the clinical consequences and characteristics of IMD in this population. With a focus on countries with advanced economies that have specific meningococcal vaccination recommendations, the epidemiology of meningococcal disease and vaccination recommendations in adolescents/young adults will also be discussed. Taylor & Francis 2018-10-29 /pmc/articles/PMC6422514/ /pubmed/30273506 http://dx.doi.org/10.1080/21645515.2018.1528831 Text en #xa9; 2018 The Author(s). Published by Taylor & Francis Group, LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Burman, Cynthia
Serra, Lidia
Nuttens, Charles
Presa, Jessica
Balmer, Paul
York, Laura
Meningococcal disease in adolescents and young adults: a review of the rationale for prevention through vaccination
title Meningococcal disease in adolescents and young adults: a review of the rationale for prevention through vaccination
title_full Meningococcal disease in adolescents and young adults: a review of the rationale for prevention through vaccination
title_fullStr Meningococcal disease in adolescents and young adults: a review of the rationale for prevention through vaccination
title_full_unstemmed Meningococcal disease in adolescents and young adults: a review of the rationale for prevention through vaccination
title_short Meningococcal disease in adolescents and young adults: a review of the rationale for prevention through vaccination
title_sort meningococcal disease in adolescents and young adults: a review of the rationale for prevention through vaccination
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422514/
https://www.ncbi.nlm.nih.gov/pubmed/30273506
http://dx.doi.org/10.1080/21645515.2018.1528831
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