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Effects of Quercetin on Tubular Cell Apoptosis and Kidney Damage in Rats Induced by Titanium Dioxide Nanoparticles

BACKGROUND: Recent studies have demonstrated that many nanoparticles have an adverse or toxic effect on the kidney. OBJECTIVE: To investigate the nephroprotective effect of quercetin (QT) against renal injury induced by titanium dioxide nanoparticles (NTiO2) in rats. METHODS: NTiO(2)-intoxicated rat...

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Autores principales: Alidadi, Hadis, Khorsandi, Layasadat, Shirani, Maryam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Penerbit Universiti Sains Malaysia 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422581/
https://www.ncbi.nlm.nih.gov/pubmed/30918457
http://dx.doi.org/10.21315/mjms2018.25.2.8
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author Alidadi, Hadis
Khorsandi, Layasadat
Shirani, Maryam
author_facet Alidadi, Hadis
Khorsandi, Layasadat
Shirani, Maryam
author_sort Alidadi, Hadis
collection PubMed
description BACKGROUND: Recent studies have demonstrated that many nanoparticles have an adverse or toxic effect on the kidney. OBJECTIVE: To investigate the nephroprotective effect of quercetin (QT) against renal injury induced by titanium dioxide nanoparticles (NTiO2) in rats. METHODS: NTiO(2)-intoxicated rats received 50 mg/kg of NTiO(2) for seven days. The QT + NTiO(2) group was pretreated with QT for seven days before being administered NTiO(2). Uric acid, creatinine, and blood urea nitrogen were considered to be biomarkers of nephrotoxicity. Catalase (CAT) and superoxide dismutase (SOD) activities and renal levels of malondialdehyde (MDA) were measured to assess the oxidative stress caused by NTiO(2). RESULTS: NTiO(2) significantly increased the plasma level of the biomarkers. It also significantly decreased the activities of CAT (P = 0.008) and SOD (P = 0.004), and significantly increased the MDA levels (P = 0.007). NTiO(2) caused proximal tubule damage, the accumulation of red blood cells, the infiltration of inflammatory cells, and reduced the glomerular diameters, as well as induced apoptosis in the proximal tubules. Pre-treatment with QT attenuated the histological changes, normalised the plasma biomarkers, suppressed oxidative stress, ameliorated the activities of CAT (P = 0.007) and SOD (P = 0.006), and reduced apoptosis (P < 0.001). CONCLUSION: QT was found to have a potent protective effect against nephrotoxicity induced by NTiO(2) in rats. It also reduced apoptosis caused by NTiO(2).
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spelling pubmed-64225812019-03-27 Effects of Quercetin on Tubular Cell Apoptosis and Kidney Damage in Rats Induced by Titanium Dioxide Nanoparticles Alidadi, Hadis Khorsandi, Layasadat Shirani, Maryam Malays J Med Sci Original Article BACKGROUND: Recent studies have demonstrated that many nanoparticles have an adverse or toxic effect on the kidney. OBJECTIVE: To investigate the nephroprotective effect of quercetin (QT) against renal injury induced by titanium dioxide nanoparticles (NTiO2) in rats. METHODS: NTiO(2)-intoxicated rats received 50 mg/kg of NTiO(2) for seven days. The QT + NTiO(2) group was pretreated with QT for seven days before being administered NTiO(2). Uric acid, creatinine, and blood urea nitrogen were considered to be biomarkers of nephrotoxicity. Catalase (CAT) and superoxide dismutase (SOD) activities and renal levels of malondialdehyde (MDA) were measured to assess the oxidative stress caused by NTiO(2). RESULTS: NTiO(2) significantly increased the plasma level of the biomarkers. It also significantly decreased the activities of CAT (P = 0.008) and SOD (P = 0.004), and significantly increased the MDA levels (P = 0.007). NTiO(2) caused proximal tubule damage, the accumulation of red blood cells, the infiltration of inflammatory cells, and reduced the glomerular diameters, as well as induced apoptosis in the proximal tubules. Pre-treatment with QT attenuated the histological changes, normalised the plasma biomarkers, suppressed oxidative stress, ameliorated the activities of CAT (P = 0.007) and SOD (P = 0.006), and reduced apoptosis (P < 0.001). CONCLUSION: QT was found to have a potent protective effect against nephrotoxicity induced by NTiO(2) in rats. It also reduced apoptosis caused by NTiO(2). Penerbit Universiti Sains Malaysia 2018-03 2018-04-27 /pmc/articles/PMC6422581/ /pubmed/30918457 http://dx.doi.org/10.21315/mjms2018.25.2.8 Text en © Penerbit Universiti Sains Malaysia, 2018 This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Alidadi, Hadis
Khorsandi, Layasadat
Shirani, Maryam
Effects of Quercetin on Tubular Cell Apoptosis and Kidney Damage in Rats Induced by Titanium Dioxide Nanoparticles
title Effects of Quercetin on Tubular Cell Apoptosis and Kidney Damage in Rats Induced by Titanium Dioxide Nanoparticles
title_full Effects of Quercetin on Tubular Cell Apoptosis and Kidney Damage in Rats Induced by Titanium Dioxide Nanoparticles
title_fullStr Effects of Quercetin on Tubular Cell Apoptosis and Kidney Damage in Rats Induced by Titanium Dioxide Nanoparticles
title_full_unstemmed Effects of Quercetin on Tubular Cell Apoptosis and Kidney Damage in Rats Induced by Titanium Dioxide Nanoparticles
title_short Effects of Quercetin on Tubular Cell Apoptosis and Kidney Damage in Rats Induced by Titanium Dioxide Nanoparticles
title_sort effects of quercetin on tubular cell apoptosis and kidney damage in rats induced by titanium dioxide nanoparticles
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422581/
https://www.ncbi.nlm.nih.gov/pubmed/30918457
http://dx.doi.org/10.21315/mjms2018.25.2.8
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