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Application of (82)Sr/(82)Rb generator in neurooncology

INTRODUCTION: The applicability of “Rubidium Chloride, (82)Rb from Generator” radiopharmaceutical for brain tumors (BT) diagnostics is demonstrated on the basis of the application experience of the radiopharmaceutical in neurooncology. EXPERIMENTAL: A total of 21 patients with various brain tumors a...

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Autores principales: Kostenikov, Nikolay A., Zhuikov, Boris L., Chudakov, Valeriy M., Iliuschenko, Yuriy R., Shatik, Sergey V., Zaitsev, Vadim V., Sysoev, Dmitriy S., Stanzhevskiy, Andrey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422714/
https://www.ncbi.nlm.nih.gov/pubmed/30729720
http://dx.doi.org/10.1002/brb3.1212
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author Kostenikov, Nikolay A.
Zhuikov, Boris L.
Chudakov, Valeriy M.
Iliuschenko, Yuriy R.
Shatik, Sergey V.
Zaitsev, Vadim V.
Sysoev, Dmitriy S.
Stanzhevskiy, Andrey A.
author_facet Kostenikov, Nikolay A.
Zhuikov, Boris L.
Chudakov, Valeriy M.
Iliuschenko, Yuriy R.
Shatik, Sergey V.
Zaitsev, Vadim V.
Sysoev, Dmitriy S.
Stanzhevskiy, Andrey A.
author_sort Kostenikov, Nikolay A.
collection PubMed
description INTRODUCTION: The applicability of “Rubidium Chloride, (82)Rb from Generator” radiopharmaceutical for brain tumors (BT) diagnostics is demonstrated on the basis of the application experience of the radiopharmaceutical in neurooncology. EXPERIMENTAL: A total of 21 patients with various brain tumors and nonneoplastic abnormal brain masses were investigated. RESULTS AND DISCUSSIONS: The results of the imaging and differential diagnostics of malignant and benign tumors, nonneoplastic abnormal brain masses and lesions revealed the prevalence of high uptake of the radiopharmaceutical in the malignant tumors in comparison with benign glioma and arteriovenous malformations in which (82)Rb‐chloride accumulates in the vascular phase but does not linger further. The ultra‐short half‐life of radionuclide (82)Rb (76 s) along with a low absorbed radiation dose with (82)Rb‐chloride by intravenous administration create a new possibility of successive use of two or more radiopharmaceuticals for the examination of the same patient. For instance, PET examination with (18)F‐FDG, (11)C‐methionine, (11)C‐choline, or any other radiopharmaceutical can be carried out in just 7–15 min. after (82)Rb‐chloride injection. CONCLUSION: Research demonstrated an effectiveness of (82)Rb‐chloride application as a diagnostic agent in neurooncology. A method of dosing and administration of the generator‐produced radiopharmaceutical has been worked out. It is possible to do up to 600 PET sessions using one Russian (82)Rb generator GR‐01. The generator is proved to be reliable and easy to use. The interest in (82)Rb‐chloride as a tumor‐seeking radiopharmaceutical rose due to the active application of the modern devices PET/CT in the routine clinical practice.
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spelling pubmed-64227142019-03-28 Application of (82)Sr/(82)Rb generator in neurooncology Kostenikov, Nikolay A. Zhuikov, Boris L. Chudakov, Valeriy M. Iliuschenko, Yuriy R. Shatik, Sergey V. Zaitsev, Vadim V. Sysoev, Dmitriy S. Stanzhevskiy, Andrey A. Brain Behav Original Research INTRODUCTION: The applicability of “Rubidium Chloride, (82)Rb from Generator” radiopharmaceutical for brain tumors (BT) diagnostics is demonstrated on the basis of the application experience of the radiopharmaceutical in neurooncology. EXPERIMENTAL: A total of 21 patients with various brain tumors and nonneoplastic abnormal brain masses were investigated. RESULTS AND DISCUSSIONS: The results of the imaging and differential diagnostics of malignant and benign tumors, nonneoplastic abnormal brain masses and lesions revealed the prevalence of high uptake of the radiopharmaceutical in the malignant tumors in comparison with benign glioma and arteriovenous malformations in which (82)Rb‐chloride accumulates in the vascular phase but does not linger further. The ultra‐short half‐life of radionuclide (82)Rb (76 s) along with a low absorbed radiation dose with (82)Rb‐chloride by intravenous administration create a new possibility of successive use of two or more radiopharmaceuticals for the examination of the same patient. For instance, PET examination with (18)F‐FDG, (11)C‐methionine, (11)C‐choline, or any other radiopharmaceutical can be carried out in just 7–15 min. after (82)Rb‐chloride injection. CONCLUSION: Research demonstrated an effectiveness of (82)Rb‐chloride application as a diagnostic agent in neurooncology. A method of dosing and administration of the generator‐produced radiopharmaceutical has been worked out. It is possible to do up to 600 PET sessions using one Russian (82)Rb generator GR‐01. The generator is proved to be reliable and easy to use. The interest in (82)Rb‐chloride as a tumor‐seeking radiopharmaceutical rose due to the active application of the modern devices PET/CT in the routine clinical practice. John Wiley and Sons Inc. 2019-02-06 /pmc/articles/PMC6422714/ /pubmed/30729720 http://dx.doi.org/10.1002/brb3.1212 Text en © 2019 Institution for Nuclear Research of Russian Academy of Science (INR RAS) Brain and Behavior Published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Kostenikov, Nikolay A.
Zhuikov, Boris L.
Chudakov, Valeriy M.
Iliuschenko, Yuriy R.
Shatik, Sergey V.
Zaitsev, Vadim V.
Sysoev, Dmitriy S.
Stanzhevskiy, Andrey A.
Application of (82)Sr/(82)Rb generator in neurooncology
title Application of (82)Sr/(82)Rb generator in neurooncology
title_full Application of (82)Sr/(82)Rb generator in neurooncology
title_fullStr Application of (82)Sr/(82)Rb generator in neurooncology
title_full_unstemmed Application of (82)Sr/(82)Rb generator in neurooncology
title_short Application of (82)Sr/(82)Rb generator in neurooncology
title_sort application of (82)sr/(82)rb generator in neurooncology
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422714/
https://www.ncbi.nlm.nih.gov/pubmed/30729720
http://dx.doi.org/10.1002/brb3.1212
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