Potential therapeutic targets for atherosclerosis in sphingolipid metabolism

Sphingolipids, such as sphingomyelins, ceramides, glycosphingolipids, and sphingosine-1-phosphates (S1P) are a large group of structurally and functionally diverse molecules. Some specific species are found associated with atherogenesis and provide novel therapeutic targets. Herein, we briefly revie...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Zemou, Peng, Qing, Huang, Yining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422862/
https://www.ncbi.nlm.nih.gov/pubmed/30890654
http://dx.doi.org/10.1042/CS20180911
_version_ 1783404427237916672
author Yu, Zemou
Peng, Qing
Huang, Yining
author_facet Yu, Zemou
Peng, Qing
Huang, Yining
author_sort Yu, Zemou
collection PubMed
description Sphingolipids, such as sphingomyelins, ceramides, glycosphingolipids, and sphingosine-1-phosphates (S1P) are a large group of structurally and functionally diverse molecules. Some specific species are found associated with atherogenesis and provide novel therapeutic targets. Herein, we briefly review how sphingolipids are implicated in the progression of atherosclerosis and related diseases, and then we discuss the potential therapy options by targetting several key enzymes in sphingolipid metabolism.
format Online
Article
Text
id pubmed-6422862
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Portland Press Ltd.
record_format MEDLINE/PubMed
spelling pubmed-64228622019-03-27 Potential therapeutic targets for atherosclerosis in sphingolipid metabolism Yu, Zemou Peng, Qing Huang, Yining Clin Sci (Lond) Review Articles Sphingolipids, such as sphingomyelins, ceramides, glycosphingolipids, and sphingosine-1-phosphates (S1P) are a large group of structurally and functionally diverse molecules. Some specific species are found associated with atherogenesis and provide novel therapeutic targets. Herein, we briefly review how sphingolipids are implicated in the progression of atherosclerosis and related diseases, and then we discuss the potential therapy options by targetting several key enzymes in sphingolipid metabolism. Portland Press Ltd. 2019-03-19 /pmc/articles/PMC6422862/ /pubmed/30890654 http://dx.doi.org/10.1042/CS20180911 Text en © 2019 The Author(s). https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Review Articles
Yu, Zemou
Peng, Qing
Huang, Yining
Potential therapeutic targets for atherosclerosis in sphingolipid metabolism
title Potential therapeutic targets for atherosclerosis in sphingolipid metabolism
title_full Potential therapeutic targets for atherosclerosis in sphingolipid metabolism
title_fullStr Potential therapeutic targets for atherosclerosis in sphingolipid metabolism
title_full_unstemmed Potential therapeutic targets for atherosclerosis in sphingolipid metabolism
title_short Potential therapeutic targets for atherosclerosis in sphingolipid metabolism
title_sort potential therapeutic targets for atherosclerosis in sphingolipid metabolism
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422862/
https://www.ncbi.nlm.nih.gov/pubmed/30890654
http://dx.doi.org/10.1042/CS20180911
work_keys_str_mv AT yuzemou potentialtherapeutictargetsforatherosclerosisinsphingolipidmetabolism
AT pengqing potentialtherapeutictargetsforatherosclerosisinsphingolipidmetabolism
AT huangyining potentialtherapeutictargetsforatherosclerosisinsphingolipidmetabolism

Ejemplares similares