Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation

Chronic infections of the fallopian tubes with Chlamydia trachomatis (Ctr) cause scarring and can lead to infertility. Here we use human fallopian tube organoids and genital Ctr serovars D, K and E for long-term in vitro analysis. The epithelial monolayer responds with active expulsion of the bacter...

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Detalles Bibliográficos
Autores principales: Kessler, Mirjana, Hoffmann, Karen, Fritsche, Kristin, Brinkmann, Volker, Mollenkopf, Hans-Joachim, Thieck, Oliver, Teixeira da Costa, Ana Rita, Braicu, Elena I., Sehouli, Jalid, Mangler, Mandy, Berger, Hilmar, Meyer, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423033/
https://www.ncbi.nlm.nih.gov/pubmed/30886143
http://dx.doi.org/10.1038/s41467-019-09144-7

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