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Function and Immunogenicity of Gene-corrected iPSC-derived Hepatocyte-Like Cells in Restoring Low Density Lipoprotein Uptake in Homozygous Familial Hypercholesterolemia

Gene correction of induced pluripotent stem cells (iPSCs) has therapeutic potential for treating homozygous familial hypercholesterolemia (HoFH) associated with low-density lipoprotein (LDL) receptor (LDLR) dysfunction. However, few data exist regarding the functional recovery and immunogenicity of...

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Detalles Bibliográficos
Autores principales:	Okada, Hirofumi, Nakanishi, Chiaki, Yoshida, Shohei, Shimojima, Masaya, Yokawa, Junichiro, Mori, Masayuki, Tada, Hayato, Yoshimuta, Tsuyoshi, Hayashi, Kenshi, Yamano, Tomoyoshi, Hanayama, Rikinari, Yamagishi, Masakazu, Kawashiri, Masa-aki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423040/ https://www.ncbi.nlm.nih.gov/pubmed/30886174 http://dx.doi.org/10.1038/s41598-019-41056-w

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