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Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses
Cyclic helix B peptide (CHBP) is a peptide derivant of erythropoietin with powerful tissue-protective efficacies in a variety of organ injuries, but without erythropoietic effect. However, the role of CHBP in acute myocardial infarction (AMI) and related mechanisms are not studied yet. In this study...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423043/ https://www.ncbi.nlm.nih.gov/pubmed/30911412 http://dx.doi.org/10.1038/s41420-019-0161-y |
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author | Yang, Cheng Zhang, Chao Jia, Jianguo Wang, Lingyan Zhang, Weitao Li, Jiawei Xu, Ming Rong, Ruiming Zhu, Tongyu |
author_facet | Yang, Cheng Zhang, Chao Jia, Jianguo Wang, Lingyan Zhang, Weitao Li, Jiawei Xu, Ming Rong, Ruiming Zhu, Tongyu |
author_sort | Yang, Cheng |
collection | PubMed |
description | Cyclic helix B peptide (CHBP) is a peptide derivant of erythropoietin with powerful tissue-protective efficacies in a variety of organ injuries, but without erythropoietic effect. However, the role of CHBP in acute myocardial infarction (AMI) and related mechanisms are not studied yet. In this study, we found in a murine AMI model that the administration of CHBP could ameliorate cardiac injury, increase the survival rate, inhibit cardiomyocyte apoptosis, improve cardiac function and remodeling, and reduce the expression of inflammatory cytokines in the serum and kidney tissue both at 24 h and 8 weeks following AMI. This study suggests that CHBP has the potential to be used as an effective drug in the treatment of AMI. |
format | Online Article Text |
id | pubmed-6423043 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64230432019-03-25 Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses Yang, Cheng Zhang, Chao Jia, Jianguo Wang, Lingyan Zhang, Weitao Li, Jiawei Xu, Ming Rong, Ruiming Zhu, Tongyu Cell Death Discov Article Cyclic helix B peptide (CHBP) is a peptide derivant of erythropoietin with powerful tissue-protective efficacies in a variety of organ injuries, but without erythropoietic effect. However, the role of CHBP in acute myocardial infarction (AMI) and related mechanisms are not studied yet. In this study, we found in a murine AMI model that the administration of CHBP could ameliorate cardiac injury, increase the survival rate, inhibit cardiomyocyte apoptosis, improve cardiac function and remodeling, and reduce the expression of inflammatory cytokines in the serum and kidney tissue both at 24 h and 8 weeks following AMI. This study suggests that CHBP has the potential to be used as an effective drug in the treatment of AMI. Nature Publishing Group UK 2019-03-18 /pmc/articles/PMC6423043/ /pubmed/30911412 http://dx.doi.org/10.1038/s41420-019-0161-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Yang, Cheng Zhang, Chao Jia, Jianguo Wang, Lingyan Zhang, Weitao Li, Jiawei Xu, Ming Rong, Ruiming Zhu, Tongyu Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses |
title | Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses |
title_full | Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses |
title_fullStr | Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses |
title_full_unstemmed | Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses |
title_short | Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses |
title_sort | cyclic helix b peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423043/ https://www.ncbi.nlm.nih.gov/pubmed/30911412 http://dx.doi.org/10.1038/s41420-019-0161-y |
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