Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses

Cyclic helix B peptide (CHBP) is a peptide derivant of erythropoietin with powerful tissue-protective efficacies in a variety of organ injuries, but without erythropoietic effect. However, the role of CHBP in acute myocardial infarction (AMI) and related mechanisms are not studied yet. In this study...

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Autores principales: Yang, Cheng, Zhang, Chao, Jia, Jianguo, Wang, Lingyan, Zhang, Weitao, Li, Jiawei, Xu, Ming, Rong, Ruiming, Zhu, Tongyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423043/
https://www.ncbi.nlm.nih.gov/pubmed/30911412
http://dx.doi.org/10.1038/s41420-019-0161-y
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author Yang, Cheng
Zhang, Chao
Jia, Jianguo
Wang, Lingyan
Zhang, Weitao
Li, Jiawei
Xu, Ming
Rong, Ruiming
Zhu, Tongyu
author_facet Yang, Cheng
Zhang, Chao
Jia, Jianguo
Wang, Lingyan
Zhang, Weitao
Li, Jiawei
Xu, Ming
Rong, Ruiming
Zhu, Tongyu
author_sort Yang, Cheng
collection PubMed
description Cyclic helix B peptide (CHBP) is a peptide derivant of erythropoietin with powerful tissue-protective efficacies in a variety of organ injuries, but without erythropoietic effect. However, the role of CHBP in acute myocardial infarction (AMI) and related mechanisms are not studied yet. In this study, we found in a murine AMI model that the administration of CHBP could ameliorate cardiac injury, increase the survival rate, inhibit cardiomyocyte apoptosis, improve cardiac function and remodeling, and reduce the expression of inflammatory cytokines in the serum and kidney tissue both at 24 h and 8 weeks following AMI. This study suggests that CHBP has the potential to be used as an effective drug in the treatment of AMI.
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spelling pubmed-64230432019-03-25 Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses Yang, Cheng Zhang, Chao Jia, Jianguo Wang, Lingyan Zhang, Weitao Li, Jiawei Xu, Ming Rong, Ruiming Zhu, Tongyu Cell Death Discov Article Cyclic helix B peptide (CHBP) is a peptide derivant of erythropoietin with powerful tissue-protective efficacies in a variety of organ injuries, but without erythropoietic effect. However, the role of CHBP in acute myocardial infarction (AMI) and related mechanisms are not studied yet. In this study, we found in a murine AMI model that the administration of CHBP could ameliorate cardiac injury, increase the survival rate, inhibit cardiomyocyte apoptosis, improve cardiac function and remodeling, and reduce the expression of inflammatory cytokines in the serum and kidney tissue both at 24 h and 8 weeks following AMI. This study suggests that CHBP has the potential to be used as an effective drug in the treatment of AMI. Nature Publishing Group UK 2019-03-18 /pmc/articles/PMC6423043/ /pubmed/30911412 http://dx.doi.org/10.1038/s41420-019-0161-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yang, Cheng
Zhang, Chao
Jia, Jianguo
Wang, Lingyan
Zhang, Weitao
Li, Jiawei
Xu, Ming
Rong, Ruiming
Zhu, Tongyu
Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses
title Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses
title_full Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses
title_fullStr Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses
title_full_unstemmed Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses
title_short Cyclic helix B peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses
title_sort cyclic helix b peptide ameliorates acute myocardial infarction in mice by inhibiting apoptosis and inflammatory responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423043/
https://www.ncbi.nlm.nih.gov/pubmed/30911412
http://dx.doi.org/10.1038/s41420-019-0161-y
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