Cargando…

Investigation of TNBC in vitro Antiproliferative Effects of Versatile Pirrolo[1,2-a]quinoxaline Compounds

The triple-negative breast cancer (TNBC) is characterized by a more aggressive nature and poorer prognosis, nowadays none pharmaceutical approach is still available. For this reason, the research of new active compounds and attractive targets represents an interesting field. In this context MDA- MB-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Perri, Mariarita, Aiello, Francesca, Cione, Erika, Carullo, Gabriele, Amendola, Luisa, Mazzotta, Sarah, Caroleo, Maria Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423061/ https://www.ncbi.nlm.nih.gov/pubmed/30915341 http://dx.doi.org/10.3389/fmolb.2019.00012

Ejemplares similares

Soluble peptidoglycan fragments produced by Limosilactobacillus fermentum with antiproliferative activity are suitable for potential therapeutic development: A preliminary report
por: Fuochi, Virginia, et al.
Publicado: (2023)

Application of Fragment-Based Drug Discovery to Versatile Targets
por: Li, Qingxin
Publicado: (2020)

Editorial: Design, Synthesis, and Preclinical Testing of Innovative Anti-Cancer Compounds With a High Level of Selectivity of Action and Low Toxicity
por: Ferreira, Ana Maria Da Costa, et al.
Publicado: (2022)

The Chaperonin GroEL: A Versatile Tool for Applied Biotechnology Platforms
por: O'Neil, Pierce T., et al.
Publicado: (2018)

RNA Splicing: A Versatile Regulatory Mechanism in Pediatric Liver Diseases
por: Zhou, Jian-Li, et al.
Publicado: (2021)

Dual Effect of Ziconotide in Primary Erythromelalgia
por: Russo, Rosario, et al.
Publicado: (2015)

Carbonic anhydrase versatility: from pH regulation to CO(2) sensing and metabolism
por: Supuran, Claudiu T.
Publicado: (2023)

The Multi-Level Mechanism of Action of a Pan-Ras Inhibitor Explains its Antiproliferative Activity on Cetuximab-Resistant Cancer Cells
por: Tisi, Renata, et al.
Publicado: (2021)

Bacterial hemerythrin domain-containing oxygen and redox sensors: Versatile roles for oxygen and redox signaling
por: Kitanishi, Kenichi
Publicado: (2022)

Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles, Cell Viability, and Tumor Progression
por: van Solinge, Thomas S., et al.
Publicado: (2020)

Assessing the role of membrane lipids in the action of ruthenium(III) anticancer compounds
por: Starosta, Radoslaw, et al.
Publicado: (2023)

Capsaicin Analogues Derived from n-3 Polyunsaturated Fatty Acids (PUFAs) Reduce Inflammatory Activity of Macrophages and Stimulate Insulin Secretion by β-Cells In Vitro
por: Cione, Erika, et al.
Publicado: (2019)

CAT-CPI: Combining CNN and transformer to learn compound image features for predicting compound-protein interactions
por: Qian, Ying, et al.
Publicado: (2022)

Glycomimetic antagonists of BC2L-C lectin: insights from molecular dynamics simulations
por: Antonini, Giulia, et al.
Publicado: (2023)

The role of sulfur compounds in chronic obstructive pulmonary disease
por: Jiang, Simin, et al.
Publicado: (2022)

Anticancer Compounds Based on Isatin-Derivatives: Strategies to Ameliorate Selectivity and Efficiency
por: Ferraz de Paiva, Raphael Enoque, et al.
Publicado: (2021)

Thioredoxin Reductase Inhibitors as Potential Antitumors: Mercury Compounds Efficacy in Glioma Cells
por: Pires, Vanessa, et al.
Publicado: (2022)

Small-molecule compound from AlphaScreen disrupts tau-glycan interface
por: Faris, Shannon, et al.
Publicado: (2022)

SeamDock: An Interactive and Collaborative Online Docking Resource to Assist Small Compound Molecular Docking
por: Murail, Samuel, et al.
Publicado: (2021)

In silico Screening of Natural Phytocompounds Towards Identification of Potential Lead Compounds to Treat COVID-19
por: Sankar, Muthumanickam, et al.
Publicado: (2021)

PreBINDS: An Interactive Web Tool to Create Appropriate Datasets for Predicting Compound–Protein Interactions
por: Ikeda, Kazuyoshi, et al.
Publicado: (2021)

Implications of trimethylamine N-oxide (TMAO) and Betaine in Human Health: Beyond Being Osmoprotective Compounds
por: Ilyas, Ashal, et al.
Publicado: (2022)

Metabolic Pattern of Systemic Sclerosis: Association of Changes in Plasma Concentrations of Amino Acid-Related Compounds With Disease Presentation
por: Smolenska, Zaneta, et al.
Publicado: (2020)

Microbial Metabolites: The Emerging Hotspot of Antiviral Compounds as Potential Candidates to Avert Viral Pandemic Alike COVID-19
por: Raihan, Topu, et al.
Publicado: (2021)

3D- and 2D-QSAR models’ study and molecular docking of novel nitrogen-mustard compounds for osteosarcoma
por: Zhuo, Wenkun, et al.
Publicado: (2023)

Bioinformatic Prediction of Possible Targets and Mechanisms of Action of the Green Tea Compound Epigallocatechin-3-Gallate Against Breast Cancer
por: Song, Xinqiang, et al.
Publicado: (2017)

New Insights Into Potential Benefits of Bioactive Compounds of Bee Products on COVID-19: A Review and Assessment of Recent Research
por: Elmahallawy, Ehab Kotb, et al.
Publicado: (2021)

Microsecond-long simulation reveals the molecular mechanism for the dual inhibition of falcipain-2 and falcipain-3 by antimalarial lead compounds
por: Danazumi, Ammar Usman, et al.
Publicado: (2022)

Biochemical profiling of metabolomics in heavy metal-intoxicated impaired metabolism and its amelioration using plant-based bioactive compound
por: Yaqoob, Azka, et al.
Publicado: (2022)

Phenotype-based drug screening: An in vivo strategy to classify and identify the chemical compounds modulating zebrafish M-cell regeneration
por: Kumari, Ankita, et al.
Publicado: (2022)

Identification of novel compound heterozygous variants in the DNAH1 gene of a Chinese family with left-right asymmetry disorder
por: Yuan, Lamei, et al.
Publicado: (2023)

The intriguing dose-dependent effect of selected amphiphilic compounds on insulin amyloid aggregation: Focus on a cholesterol-based detergent, Chobimalt
por: Siposova, Katarina, et al.
Publicado: (2022)

Editorial: Interaction of Biomolecules and Bioactive Compounds With the SARS-CoV-2 Proteins: Molecular Simulations for the Fight Against Covid-19
por: Falconi, Mattia, et al.
Publicado: (2022)

Corrigendum: Phenotype-based drug screening: An in vivo strategy to classify and identify the chemical compounds modulating zebrafish M-cell regeneration
por: Kumari, Ankita, et al.
Publicado: (2023)

Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis
por: Wang, Qiantao, et al.
Publicado: (2015)

Molecular Docking Studies on the Anti-viral Effects of Compounds From Kabasura Kudineer on SARS-CoV-2 3CL(pro)
por: Vincent, Savariar, et al.
Publicado: (2020)

Identification of Potential Binders of Mtb Universal Stress Protein (Rv1636) Through an in silico Approach and Insights Into Compound Selection for Experimental Validation
por: Chakraborti, Sohini, et al.
Publicado: (2021)

In silico Screening of Natural Compounds as Potential Inhibitors of SARS-CoV-2 Main Protease and Spike RBD: Targets for COVID-19
por: Teli, Divya M., et al.
Publicado: (2021)

Potential use of gold-silver core-shell nanoparticles derived from Garcinia mangostana peel for anticancer compound, protocatechuic acid delivery
por: Lee, Kar Xin, et al.
Publicado: (2022)

Dipeptidyl peptidase-4 inhibitory potentials of Glycyrrhiza uralensis and its bioactive compounds licochalcone A and licochalcone B: An in silico and in vitro study
por: Shaikh, Sibhghatulla, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_snp5e77bhhu5osjpdaei8em2cj