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Mutating for Good: DNA Damage Responses During Somatic Hypermutation

Somatic hypermutation (SHM) of immunoglobulin (Ig) genes plays a key role in antibody mediated immunity. SHM in B cells provides the molecular basis for affinity maturation of antibodies. In this way SHM is key in optimizing antibody dependent immune responses. SHM is initiated by targeting the Acti...

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Detalles Bibliográficos
Autores principales:	Pilzecker, Bas, Jacobs, Heinz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423074/ https://www.ncbi.nlm.nih.gov/pubmed/30915081 http://dx.doi.org/10.3389/fimmu.2019.00438

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