Cargando…
TRPM2 Channel in Microglia as a New Player in Neuroinflammation Associated With a Spectrum of Central Nervous System Pathologies
Microglial cells in the central nervous system (CNS) are crucial in maintaining a healthy environment for neurons to function properly. However, aberrant microglial cell activation can lead to excessive generation of neurotoxic proinflammatory mediators and neuroinflammation, which represents a cont...
Autores principales: | Malko, Philippa, Syed Mortadza, Sharifah A., McWilliam, Joseph, Jiang, Lin-Hua |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423084/ https://www.ncbi.nlm.nih.gov/pubmed/30914955 http://dx.doi.org/10.3389/fphar.2019.00239 |
Ejemplares similares
-
Predisposition to Alzheimer’s and Age-Related Brain Pathologies by PM2.5 Exposure: Perspective on the Roles of Oxidative Stress and TRPM2 Channel
por: Wang, Lu, et al.
Publicado: (2020) -
TRPM2 Channel-Mediated ROS-Sensitive Ca(2+) Signaling Mechanisms in Immune Cells
por: Syed Mortadza, Sharifah Alawieyah, et al.
Publicado: (2015) -
TRPM2 channel-mediated cell death: An important mechanism linking oxidative stress-inducing pathological factors to associated pathological conditions
por: Malko, Philippa, et al.
Publicado: (2020) -
Signalling mechanisms mediating Zn(2+)-induced TRPM2 channel activation and cell death in microglial cells
por: Mortadza, Sharifah Syed, et al.
Publicado: (2017) -
Melastatin-related transient receptor potential 2 channel in Aβ(42)-induced neuroinflammation: implications to Alzheimer’s disease mechanism and development of therapeutics
por: Wei, Linyu, et al.
Publicado: (2018)