Nitric oxide-dependent anaerobic ammonium oxidation

Nitric oxide (NO) has important functions in biology and atmospheric chemistry as a toxin, signaling molecule, ozone depleting agent and the precursor of the greenhouse gas nitrous oxide (N(2)O). Although NO is a potent oxidant, and was available on Earth earlier than oxygen, it is unclear whether N...

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Autores principales: Hu, Ziye, Wessels, Hans J. C. T., van Alen, Theo, Jetten, Mike S. M., Kartal, Boran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423088/
https://www.ncbi.nlm.nih.gov/pubmed/30886150
http://dx.doi.org/10.1038/s41467-019-09268-w
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author Hu, Ziye
Wessels, Hans J. C. T.
van Alen, Theo
Jetten, Mike S. M.
Kartal, Boran
author_facet Hu, Ziye
Wessels, Hans J. C. T.
van Alen, Theo
Jetten, Mike S. M.
Kartal, Boran
author_sort Hu, Ziye
collection PubMed
description Nitric oxide (NO) has important functions in biology and atmospheric chemistry as a toxin, signaling molecule, ozone depleting agent and the precursor of the greenhouse gas nitrous oxide (N(2)O). Although NO is a potent oxidant, and was available on Earth earlier than oxygen, it is unclear whether NO can be used by microorganisms for growth. Anaerobic ammonium-oxidizing (anammox) bacteria couple nitrite reduction to ammonium oxidation with NO and hydrazine as intermediates, and produce N(2) and nitrate. Here, we show that the anammox bacterium Kuenenia stuttgartiensis is able to grow in the absence of nitrite by coupling ammonium oxidation to NO reduction, and produce only N(2). Under these growth conditions, the transcription of proteins necessary for NO generation is downregulated. Our work has potential implications in the control of N(2)O and NO emissions from natural and manmade ecosystems, where anammox bacteria contribute significantly to N(2) release to the atmosphere. We hypothesize that microbial NO-dependent ammonium oxidation may have existed on early Earth.
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spelling pubmed-64230882019-03-20 Nitric oxide-dependent anaerobic ammonium oxidation Hu, Ziye Wessels, Hans J. C. T. van Alen, Theo Jetten, Mike S. M. Kartal, Boran Nat Commun Article Nitric oxide (NO) has important functions in biology and atmospheric chemistry as a toxin, signaling molecule, ozone depleting agent and the precursor of the greenhouse gas nitrous oxide (N(2)O). Although NO is a potent oxidant, and was available on Earth earlier than oxygen, it is unclear whether NO can be used by microorganisms for growth. Anaerobic ammonium-oxidizing (anammox) bacteria couple nitrite reduction to ammonium oxidation with NO and hydrazine as intermediates, and produce N(2) and nitrate. Here, we show that the anammox bacterium Kuenenia stuttgartiensis is able to grow in the absence of nitrite by coupling ammonium oxidation to NO reduction, and produce only N(2). Under these growth conditions, the transcription of proteins necessary for NO generation is downregulated. Our work has potential implications in the control of N(2)O and NO emissions from natural and manmade ecosystems, where anammox bacteria contribute significantly to N(2) release to the atmosphere. We hypothesize that microbial NO-dependent ammonium oxidation may have existed on early Earth. Nature Publishing Group UK 2019-03-18 /pmc/articles/PMC6423088/ /pubmed/30886150 http://dx.doi.org/10.1038/s41467-019-09268-w Text en © The Author(s) 2019 https://creativecommons.org/licenses/by/4.0/ Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hu, Ziye
Wessels, Hans J. C. T.
van Alen, Theo
Jetten, Mike S. M.
Kartal, Boran
Nitric oxide-dependent anaerobic ammonium oxidation
title Nitric oxide-dependent anaerobic ammonium oxidation
title_full Nitric oxide-dependent anaerobic ammonium oxidation
title_fullStr Nitric oxide-dependent anaerobic ammonium oxidation
title_full_unstemmed Nitric oxide-dependent anaerobic ammonium oxidation
title_short Nitric oxide-dependent anaerobic ammonium oxidation
title_sort nitric oxide-dependent anaerobic ammonium oxidation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423088/
https://www.ncbi.nlm.nih.gov/pubmed/30886150
http://dx.doi.org/10.1038/s41467-019-09268-w
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