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Reconfigurable Acrylic-tape Hybrid Microfluidics

There is a great interest in low-cost, versatile microfluidic platforms of which the fabrication processes are rapid, straightforward, and translatable to industrial mass productions. In addition, it is beneficial for microfluidic devices to be reconfigurable in the field, so that multiple functions...

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Detalles Bibliográficos
Autores principales: Ren, Yundong, Ray, Subhrodeep, Liu, Yuxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423117/
https://www.ncbi.nlm.nih.gov/pubmed/30886239
http://dx.doi.org/10.1038/s41598-019-41208-y
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author Ren, Yundong
Ray, Subhrodeep
Liu, Yuxiang
author_facet Ren, Yundong
Ray, Subhrodeep
Liu, Yuxiang
author_sort Ren, Yundong
collection PubMed
description There is a great interest in low-cost, versatile microfluidic platforms of which the fabrication processes are rapid, straightforward, and translatable to industrial mass productions. In addition, it is beneficial for microfluidic devices to be reconfigurable in the field, so that multiple functions can be realized by a minimum number of devices. Here, we present a versatile acrylic-tape platform which allows highly accessible rapid prototyping of microfluidic devices, as well as device reconfiguration to realize different functions. The clean-room-free fabrication and sealing process only requires a laser cutter, acrylic, and tapes and can be done by an untrained person in the field. We experimentally characterized the relationship between the capillary flow speed and the channel height, the latter of which can be well controlled by the fabrication process. Reconfiguration of microfluidic functions was demonstrated on a single acrylic-tape device, thanks to the reversible sealing enabled by functional tapes. Different pumping mechanisms, including on-chip pumps for better portability and syringe pumps for precise fluid control, have been employed for the demonstration of two-phase flow and droplet generation, respectively. The low-cost and versatile acrylic-tape microfluidic devices are promising tools for applications in a wide range of fields, especially for point-of-care biomedical and clinical applications.
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spelling pubmed-64231172019-03-26 Reconfigurable Acrylic-tape Hybrid Microfluidics Ren, Yundong Ray, Subhrodeep Liu, Yuxiang Sci Rep Article There is a great interest in low-cost, versatile microfluidic platforms of which the fabrication processes are rapid, straightforward, and translatable to industrial mass productions. In addition, it is beneficial for microfluidic devices to be reconfigurable in the field, so that multiple functions can be realized by a minimum number of devices. Here, we present a versatile acrylic-tape platform which allows highly accessible rapid prototyping of microfluidic devices, as well as device reconfiguration to realize different functions. The clean-room-free fabrication and sealing process only requires a laser cutter, acrylic, and tapes and can be done by an untrained person in the field. We experimentally characterized the relationship between the capillary flow speed and the channel height, the latter of which can be well controlled by the fabrication process. Reconfiguration of microfluidic functions was demonstrated on a single acrylic-tape device, thanks to the reversible sealing enabled by functional tapes. Different pumping mechanisms, including on-chip pumps for better portability and syringe pumps for precise fluid control, have been employed for the demonstration of two-phase flow and droplet generation, respectively. The low-cost and versatile acrylic-tape microfluidic devices are promising tools for applications in a wide range of fields, especially for point-of-care biomedical and clinical applications. Nature Publishing Group UK 2019-03-18 /pmc/articles/PMC6423117/ /pubmed/30886239 http://dx.doi.org/10.1038/s41598-019-41208-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ren, Yundong
Ray, Subhrodeep
Liu, Yuxiang
Reconfigurable Acrylic-tape Hybrid Microfluidics
title Reconfigurable Acrylic-tape Hybrid Microfluidics
title_full Reconfigurable Acrylic-tape Hybrid Microfluidics
title_fullStr Reconfigurable Acrylic-tape Hybrid Microfluidics
title_full_unstemmed Reconfigurable Acrylic-tape Hybrid Microfluidics
title_short Reconfigurable Acrylic-tape Hybrid Microfluidics
title_sort reconfigurable acrylic-tape hybrid microfluidics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423117/
https://www.ncbi.nlm.nih.gov/pubmed/30886239
http://dx.doi.org/10.1038/s41598-019-41208-y
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