Cargando…

Anti-HIV-1 integrase potency of methylgallate from Alchornea cordifolia using in vitro and in silico approaches

According to the 2018 report of the United Nations Programme on HIV/AIDS (UNAIDS), acquired immune deficiency syndrome (AIDS), a disease caused by the human immunodeficiency virus (HIV), remains a significant public health problem. The non-existence of a cure or effective vaccine for the disease and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siwe-Noundou, Xavier, Musyoka, Thommas M., Moses, Vuyani, Ndinteh, Derek T., Mnkandhla, Dumisani, Hoppe, Heinrich, Tastan Bishop, Özlem, Krause, Rui W. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423119/ https://www.ncbi.nlm.nih.gov/pubmed/30886338 http://dx.doi.org/10.1038/s41598-019-41403-x

Ejemplares similares

South African Abietane Diterpenoids and Their Analogs as Potential Antimalarials: Novel Insights from Hybrid Computational Approaches
por: Musyoka, Thommas, et al.
Publicado: (2019)

Development of dermopharmaceutical forms based on the fruit of Alchornea cordifolia (Euphorbiaceae) for the treatment of dermatophytes
por: Angely, Koffi Armand, et al.
Publicado: (2019)

Combinations of Alchornea cordifolia, Cassytha filiformis and Pterocarpus santalinoides in diarrhoegenic bacterial infections
por: Oli, Angus Nnamdi, et al.
Publicado: (2019)

Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design
por: Musyoka, Thommas Mutemi, et al.
Publicado: (2019)

Characterisation of plasmodial transketolases and identification of potential inhibitors: an in silico study
por: Boateng, Rita Afriyie, et al.
Publicado: (2020)

Antibacterial activities and toxicological study of the aqueous extract from leaves of Alchornea cordifolia (Euphorbiaceae)
por: Djimeli, Merline Namekong, et al.
Publicado: (2017)

Phytofabrication and characterization of Alchornea cordifolia silver nanoparticles and evaluation of antiplasmodial, hemocompatibility and larvicidal potential
por: Kojom Foko, Loick Pradel, et al.
Publicado: (2023)

Bioinformatic characterization of type-specific sequence and structural features in auxiliary activity family 9 proteins
por: Moses, Vuyani, et al.
Publicado: (2016)

Deciphering Isoniazid Drug Resistance Mechanisms on Dimeric Mycobacterium tuberculosis KatG via Post-molecular Dynamics Analyses Including Combined Dynamic Residue Network Metrics
por: Barozi, Victor, et al.
Publicado: (2022)

Characterization and Antimicrobial Activity of Volatile Constituents from Fresh Fruits of Alchornea cordifolia and Canthium subcordatum
por: Essien, Emmanuel E., et al.
Publicado: (2015)

JMS: An Open Source Workflow Management System and Web-Based Cluster Front-End for High Performance Computing
por: Brown, David K., et al.
Publicado: (2015)

Structure Based Docking and Molecular Dynamic Studies of Plasmodial Cysteine Proteases against a South African Natural Compound and its Analogs
por: Musyoka, Thommas M., et al.
Publicado: (2016)

Isolation and Characterisation of Quercitrin as a Potent Anti-Sickle Cell Anaemia Agent from Alchornea cordifolia
por: Adeniyi, Olayemi, et al.
Publicado: (2022)

Assessment of toxicity and anti-plasmodial activities of chloroform fractions of Carapa procera and Alchornea cordifolia in murine models
por: Mahama, Ayisha, et al.
Publicado: (2022)

Determining the unbinding events and conserved motions associated with the pyrazinamide release due to resistance mutations of Mycobacterium tuberculosis pyrazinamidase
por: Sheik Amamuddy, Olivier, et al.
Publicado: (2020)

Allosteric pockets and dynamic residue network hubs of falcipain 2 in mutations including those linked to artemisinin resistance
por: Okeke, Chiamaka Jessica, et al.
Publicado: (2021)

SANCDB: an update on South African natural compounds and their readily available analogs
por: Diallo, Bakary N’tji, et al.
Publicado: (2021)

Force Field Parameters for Fe(2+)(4)S(2−)(4) Clusters of Dihydropyrimidine Dehydrogenase, the 5-Fluorouracil Cancer Drug Deactivation Protein: A Step towards In Silico Pharmacogenomics Studies
por: Tendwa, Maureen Bilinga, et al.
Publicado: (2021)

Garcinia kola (Heckel) and Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg. from Cameroon possess potential antisalmonellal and antioxidant properties
por: Djague, Fred, et al.
Publicado: (2020)

Plasmodium falciparum: Assessment of Selectivity of Action of Chloroquine, Alchornea cordifolia, Ficus polita, and Other Drugs by a Tetrazolium-Based Colorimetric Assay
por: Ayisi, Nana Kofi, et al.
Publicado: (2011)

Deeper Insights on Alchornea cordifolia (Schumach. & Thonn.) Müll.Arg Extracts: Chemical Profiles, Biological Abilities, Network Analysis and Molecular Docking
por: Sinan, Kouadio Ibrahime, et al.
Publicado: (2021)

SANCDB: a South African natural compound database
por: Hatherley, Rowan, et al.
Publicado: (2015)

Botanical Medicines Cryptolepis sanguinolenta, Artemisia annua, Scutellaria baicalensis, Polygonum cuspidatum, and Alchornea cordifolia Demonstrate Inhibitory Activity Against Babesia duncani
por: Zhang, Yumin, et al.
Publicado: (2021)

Allelopathic Potency and an Active Substance from Anredera cordifolia (Tenore) Steenis
por: Bari, Ichsan Nurul, et al.
Publicado: (2019)

Euphorbia Diterpenes: An Update of Isolation, Structure, Pharmacological Activities and Structure–Activity Relationship
por: Kemboi, Douglas, et al.
Publicado: (2021)

HIV-1 Integrase Inhibitors with Modifications That Affect Their Potencies against Drug Resistant Integrase Mutants
por: Smith, Steven J., et al.
Publicado: (2021)

Antimalarial, antiplasmodial and analgesic activities of root extract of Alchornea laxiflora
por: Okokon, Jude E., et al.
Publicado: (2017)

Catalytic Performance of Immobilized Sulfuric Acid on Silica Gel for N-Formylation of Amines with Triethyl Orthoformate
por: Salami, Sodeeq Aderotimi, et al.
Publicado: (2022)

A More Sustainable Isocyanide Synthesis from N-Substituted Formamides Using Phosphorus Oxychloride in the Presence of Triethylamine as Solvent
por: Salami, Sodeeq Aderotimi, et al.
Publicado: (2022)

Identification of Novel Potential Inhibitors of Pteridine Reductase 1 in Trypanosoma brucei via Computational Structure-Based Approaches and in Vitro Inhibition Assays
por: Kimuda, Magambo Phillip, et al.
Publicado: (2019)

In Vitro and In Silico Potential Inhibitory Effects of New Biflavonoids from Ochna rhizomatosa on HIV-1 Integrase and Plasmodium falciparum
por: Messi, Angélique Nicolas, et al.
Publicado: (2022)

Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa
por: Lopes, Flávia CM, et al.
Publicado: (2009)

Evaluation of Antibacterial and Antifungal Properties of Alchornea laxiflora (Benth.) Pax. & Hoffman
por: Akinpelu, David A., et al.
Publicado: (2015)

Immobilized Sulfuric Acid on Silica Gel as Highly Efficient and Heterogeneous Catalyst for the One-Pot Synthesis of Novel α-Acyloxycarboxamides in Aqueous Media
por: Salami, Sodeeq Aderotimi, et al.
Publicado: (2022)

In vitro antibacterial and cytotoxic effects of Euphorbia grandicornis Blanc chemical constituents
por: Kemboi, Douglas, et al.
Publicado: (2022)

Effects of the Ethyl Acetate Fraction of Alchornea triplinervia on Healing Gastric Ulcer in Rats
por: Lima, Zeila P., et al.
Publicado: (2011)

Rapid Synthesis of Thiol-Co-Capped-CdTe/CdSe/ZnSe Core Shell-Shell Nanoparticles: Their Optical and Structural Morphology
por: Daramola, Olamide Abiodun, et al.
Publicado: (2021)

Potential repurposing of four FDA approved compounds with antiplasmodial activity identified through proteome scale computational drug discovery and in vitro assay
por: Diallo, Bakary N’tji, et al.
Publicado: (2021)

Tinaspora Cordifolia
por: Banerjee, D. N.
Publicado: (1894)

In vitro capacity and in vivo antioxidant potency of sedimental extract of Tinospora cordifolia in streptozotocin induced type 2 diabetes
por: Kannadhasan, Ramachandran, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_1vskh94nva7qkiloaq0svcsduh