Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s

CCR5 is a member of the G-protein coupled receptor family that serves as an essential co-receptor for cellular entry of R5-tropic HIV-1, and is a validated target for therapeutics against HIV-1 infections. In the present study, we designed and synthesized a series of novel small CCR5 inhibitors and...

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Detalles Bibliográficos
Autores principales: Nakata, Hirotomo, Maeda, Kenji, Das, Debananda, Chang, Simon B., Matsuda, Kouki, Rao, Kalapala Venkateswara, Harada, Shigeyoshi, Yoshimura, Kazuhisa, Ghosh, Arun K., Mitsuya, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423129/
https://www.ncbi.nlm.nih.gov/pubmed/30886166
http://dx.doi.org/10.1038/s41598-019-41080-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423129/
https://www.ncbi.nlm.nih.gov/pubmed/30886166
http://dx.doi.org/10.1038/s41598-019-41080-w

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