MR1 recycling and blockade of endosomal trafficking reveal distinguishable antigen presentation pathways between Mycobacterium tuberculosis infection and exogenously delivered antigens

The MHC-Ib molecule MR1 presents microbial metabolites to MR1-restricted T cells (MR1Ts). Given the ubiquitous expression of MR1 and the high prevalence of human MR1Ts, it is important to understand the mechanisms of MR1-dependent antigen presentation. Here, we show that MR1-dependent antigen presen...

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Detalles Bibliográficos
Autores principales: Karamooz, Elham, Harriff, Melanie J., Narayanan, Gitanjali A., Worley, Aneta, Lewinsohn, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423294/
https://www.ncbi.nlm.nih.gov/pubmed/30886396
http://dx.doi.org/10.1038/s41598-019-41402-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423294/
https://www.ncbi.nlm.nih.gov/pubmed/30886396
http://dx.doi.org/10.1038/s41598-019-41402-y

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