Anemia is a poor prognostic factor for stage I non-small cell lung cancer (NSCLC) patients treated with Stereotactic Body Radiation Therapy (SBRT)

• This study reports on the prognostic ability of haematological parameters for the largest known biopsy-proven stage-I medically inoperable cohort treated with SBRT. • After SBRT, the median values of Hb, ALC, ANC and TPC declined whereas the NLR and the PLR increased as compared to pre-SBRT. • Ane...

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Autores principales: Pathak, Rima S., Pantarotto, Jason R., Cook, Graham, Holmes, Oliver, Cross, Peter, MacRae, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423348/
https://www.ncbi.nlm.nih.gov/pubmed/30923751
http://dx.doi.org/10.1016/j.ctro.2019.01.003
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author Pathak, Rima S.
Pantarotto, Jason R.
Cook, Graham
Holmes, Oliver
Cross, Peter
MacRae, Robert M.
author_facet Pathak, Rima S.
Pantarotto, Jason R.
Cook, Graham
Holmes, Oliver
Cross, Peter
MacRae, Robert M.
author_sort Pathak, Rima S.
collection PubMed
description • This study reports on the prognostic ability of haematological parameters for the largest known biopsy-proven stage-I medically inoperable cohort treated with SBRT. • After SBRT, the median values of Hb, ALC, ANC and TPC declined whereas the NLR and the PLR increased as compared to pre-SBRT. • Anemia along with other parameters was found to be a poor prognostic factor for local control despite treatment with SBRT to doses of >100 Gy BED(10). • Simple and minimally invasive methods like a peripheral blood sample can provide prognostic information even for stage-I NSCLC patients. • Patient, tumor and treatment factors along with molecular markers should be used to create risk stratification models that can guide therapy.
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spelling pubmed-64233482019-03-28 Anemia is a poor prognostic factor for stage I non-small cell lung cancer (NSCLC) patients treated with Stereotactic Body Radiation Therapy (SBRT) Pathak, Rima S. Pantarotto, Jason R. Cook, Graham Holmes, Oliver Cross, Peter MacRae, Robert M. Clin Transl Radiat Oncol Article • This study reports on the prognostic ability of haematological parameters for the largest known biopsy-proven stage-I medically inoperable cohort treated with SBRT. • After SBRT, the median values of Hb, ALC, ANC and TPC declined whereas the NLR and the PLR increased as compared to pre-SBRT. • Anemia along with other parameters was found to be a poor prognostic factor for local control despite treatment with SBRT to doses of >100 Gy BED(10). • Simple and minimally invasive methods like a peripheral blood sample can provide prognostic information even for stage-I NSCLC patients. • Patient, tumor and treatment factors along with molecular markers should be used to create risk stratification models that can guide therapy. Elsevier 2019-01-24 /pmc/articles/PMC6423348/ /pubmed/30923751 http://dx.doi.org/10.1016/j.ctro.2019.01.003 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Pathak, Rima S.
Pantarotto, Jason R.
Cook, Graham
Holmes, Oliver
Cross, Peter
MacRae, Robert M.
Anemia is a poor prognostic factor for stage I non-small cell lung cancer (NSCLC) patients treated with Stereotactic Body Radiation Therapy (SBRT)
title Anemia is a poor prognostic factor for stage I non-small cell lung cancer (NSCLC) patients treated with Stereotactic Body Radiation Therapy (SBRT)
title_full Anemia is a poor prognostic factor for stage I non-small cell lung cancer (NSCLC) patients treated with Stereotactic Body Radiation Therapy (SBRT)
title_fullStr Anemia is a poor prognostic factor for stage I non-small cell lung cancer (NSCLC) patients treated with Stereotactic Body Radiation Therapy (SBRT)
title_full_unstemmed Anemia is a poor prognostic factor for stage I non-small cell lung cancer (NSCLC) patients treated with Stereotactic Body Radiation Therapy (SBRT)
title_short Anemia is a poor prognostic factor for stage I non-small cell lung cancer (NSCLC) patients treated with Stereotactic Body Radiation Therapy (SBRT)
title_sort anemia is a poor prognostic factor for stage i non-small cell lung cancer (nsclc) patients treated with stereotactic body radiation therapy (sbrt)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423348/
https://www.ncbi.nlm.nih.gov/pubmed/30923751
http://dx.doi.org/10.1016/j.ctro.2019.01.003
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