Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy

Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by loss of α-motor neurons, leading to profound skeletal muscle atrophy. Patients also suffer from decreased bone mineral density and increased fracture risk. The majority of treatments for SMA, approved or in clinic trials, focu...

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Detalles Bibliográficos
Autores principales: Long, Kimberly K, O’Shea, Karen M, Khairallah, Ramzi J, Howell, Kelly, Paushkin, Sergey, Chen, Karen S, Cote, Shaun M, Webster, Micah T, Stains, Joseph P, Treece, Erin, Buckler, Alan, Donovan, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423420/
https://www.ncbi.nlm.nih.gov/pubmed/30481286
http://dx.doi.org/10.1093/hmg/ddy382

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