Induction of Apoptosis by a Combination of 2-Deoxyglucose and Metformin in Esophageal Squamous Cell Carcinoma by Targeting Cancer Cell Metabolism

BACKGROUND: Both mitochondrial dysfunction and aerobic glycolysis are signs of growing aggressive cancer. If altered metabolism of cancer cell is intended, using the glycolysis inhibitor (2-deoxyglucose (2DG)) would be a viable therapeutic method. The AMP-activated protein kinase (AMPK), as a metabo...

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Detalles Bibliográficos
Autores principales: Shafaee, Abbas, Pirayesh Islamian, Jalil, Zarei, Davoud, Mohammadi, Mohsen, Nejati-Koshki, Kazem, Farajollahi, Alireza, Aghamiri, Seyed Mahmoud Reza, Rahmati Yamchi, Mohammad, Baradaran, Behzad, Asghari Jafarabadi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Journal of Medical Sciences 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423430/
https://www.ncbi.nlm.nih.gov/pubmed/30936596

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