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Improved mass spectrometry-based activity assay reveals oxidative and metabolic stress as sirtuin-1 regulators
Sirtuin-1 (SirT1) catalyzes NAD(+)-dependent protein lysine deacetylation and is a critical regulator of energy and lipid metabolism, mitochondrial biogenesis, apoptosis, and senescence. Activation of SirT1 mitigates metabolic perturbations associated with diabetes and obesity. Pharmacologic molecul...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423473/ https://www.ncbi.nlm.nih.gov/pubmed/30877853 http://dx.doi.org/10.1016/j.redox.2019.101150 |