Cargando…

BP-1-102 exerts an antitumor effect on the AGS human gastric cancer cell line through modulating the STAT3 and MAPK signaling pathways

BP-1-102, a novel inhibitor of signal transducer and activator of transcription 3 (STAT3), exhibits significant antitumor effects in several malignancies in vitro and in vivo. However, its role in gastric cancer (GC) remains to be elucidated. In the present study, the effect and potential molecular...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Xiaoxia, Tang, Jian, Wu, Mengjie, Chen, Shitu, Xu, Zhenzhen, Wang, Haiyong, Wang, Haohao, Yu, Xiongfei, Li, Zhongqi, Teng, Lisong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423579/ https://www.ncbi.nlm.nih.gov/pubmed/30720080 http://dx.doi.org/10.3892/mmr.2019.9892

Ejemplares similares

HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer
por: Jiang, Xiaoxia, et al.
Publicado: (2018)

Luteolin exerts a marked antitumor effect in cMet-overexpressing patient-derived tumor xenograft models of gastric cancer
por: Lu, Jun, et al.
Publicado: (2015)

BP‑1‑102 exerts antitumor effects on T‑cell acute lymphoblastic leukemia cells by suppressing the JAK2/STAT3/c‑Myc signaling pathway
por: Ye, Can, et al.
Publicado: (2023)

GPRC5A: An Emerging Biomarker in Human Cancer
por: Jiang, Xiaoxia, et al.
Publicado: (2018)

COL12A1, a novel potential prognostic factor and therapeutic target in gastric cancer
por: Jiang, Xiaoxia, et al.
Publicado: (2019)

Identification of genes associated with gastric cancer survival and construction of a nomogram to improve risk stratification for patients with gastric cancer
por: Ding, Yongfeng, et al.
Publicado: (2020)

Prognostic Value of the Combination of CEA and Fibrinogen/Albumin Ratio in Resectable Gastric Cancer
por: Zhang, Junbin, et al.
Publicado: (2020)

Advances in the targeted therapy of liposarcoma
por: Guan, Zhonghai, et al.
Publicado: (2015)

Gut microbiota shifts in patients with gastric cancer in perioperative period
por: Liang, Weiren, et al.
Publicado: (2019)

Establishment of patient-derived gastric cancer xenografts: a useful tool for preclinical evaluation of targeted therapies involving alterations in HER-2, MET and FGFR2 signaling pathways
por: Wang, Haiyong, et al.
Publicado: (2017)

LncRNA MIR4435-2HG targets desmoplakin and promotes growth and metastasis of gastric cancer by activating Wnt/β-catenin signaling
por: Wang, Haiyong, et al.
Publicado: (2019)

The decay of 8 min $^{102m}$Ag and 13 min $^{102g}$Ag
por: Hnatowich, D J, et al.
Publicado: (1971)

Design, synthesis, and in vitro evaluation of BP-1-102 analogs with modified hydrophobic fragments for STAT3 inhibition
por: Oleksak, Patrik, et al.
Publicado: (2021)

Patient-derived xenograft models for gastrointestinal tumors: A single-center retrospective study
por: Yu, Xiongfei, et al.
Publicado: (2022)

A Gene Regulatory Network Controlled by BpERF2 and BpMYB102 in Birch under Drought Conditions
por: Wen, Xuejing, et al.
Publicado: (2019)

Whole-exome sequencing of alpha-fetoprotein producing gastric carcinoma reveals genomic profile and therapeutic targets
por: Lu, Jun, et al.
Publicado: (2021)

Combining the Fibrinogen/Albumin Ratio and Systemic Inflammation Response Index Predicts Survival in Resectable Gastric Cancer
por: Zhang, Junbin, et al.
Publicado: (2020)

Pharmacological inhibition of STAT3 by BP‐1‐102 inhibits intracranial aneurysm formation and rupture in mice through modulating inflammatory response
por: Jiang, Zhixian, et al.
Publicado: (2021)

Overexpressed MAGP1 Is Associated With a Poor Prognosis and Promotes Cell Migration and Invasion in Gastric Cancer
por: Wu, Mengjie, et al.
Publicado: (2020)

Synergistic antitumor effects of cMet inhibitor in combination with anti-VEGF in colorectal cancer patient-derived xenograft models
por: Chen, Xiangheng, et al.
Publicado: (2018)

Carbon Nanospheres Exert Antitumor Effects Associated with Downregulation of 4E-BP1 Expression on Prostate Cancer
por: Dong, Weimin, et al.
Publicado: (2020)

Efficacy and safety of neoadjuvant sintilimab, oxaliplatin and capecitabine in patients with locally advanced, resectable gastric or gastroesophageal junction adenocarcinoma: early results of a phase 2 study
por: Jiang, Haiping, et al.
Publicado: (2022)

MiR-301a-5p/SCIN promotes gastric cancer progression via regulating STAT3 and NF-κB signaling
por: Huang, Yingying, et al.
Publicado: (2021)

FH535 Inhibits Proliferation and Motility of Colon Cancer Cells by Targeting Wnt/β-catenin Signaling Pathway
por: Chen, Yanyan, et al.
Publicado: (2017)

Antitumor effect of toosendanin on oral squamous cell carcinoma via suppression of p-STAT3
por: Wu, Ye, et al.
Publicado: (2023)

Identification and Validation of a Prognostic Signature for Thyroid Cancer Based on Ferroptosis-Related Genes
por: Wang, Yue, et al.
Publicado: (2022)

Identification of TYROBP and C1QB as Two Novel Key Genes With Prognostic Value in Gastric Cancer by Network Analysis
por: Jiang, Junjie, et al.
Publicado: (2020)

Gimatecan exerts potent antitumor activity against gastric cancer in vitro and in vivo via AKT and MAPK signaling pathways
por: Chen, Zuhua, et al.
Publicado: (2017)

Cinobufagin exerts an antitumor effect in non-small-cell lung cancer by blocking STAT3 signaling
por: Yan, Sunshun, et al.
Publicado: (2023)

Integrated genomic analysis identifies a genetic mutation model predicting response to immune checkpoint inhibitors in melanoma
por: Jiang, Junjie, et al.
Publicado: (2020)

EXOSC5 promotes proliferation of gastric cancer through regulating AKT/STAT3 signaling pathways
por: Chen, Xiangliu, et al.
Publicado: (2022)

Anti‐PD‐1/Her2 Bispecific Antibody IBI315 Enhances the Treatment Effect of Her2‐Positive Gastric Cancer through Gasdermin B‐Cleavage Induced Pyroptosis (Adv. Sci. 30/2023)
por: Lin, Wu, et al.
Publicado: (2023)

Anti‐PD‐1/Her2 Bispecific Antibody IBI315 Enhances the Treatment Effect of Her2‐Positive Gastric Cancer through Gasdermin B‐Cleavage Induced Pyroptosis
por: Lin, Wu, et al.
Publicado: (2023)

Association of telomerase reverse transcriptase promoter mutations with clinicopathological features and prognosis of thyroid cancer: a meta-analysis
por: Su, Xingyun, et al.
Publicado: (2016)

Alternol, a natural compound, exerts an anti‐tumour effect on osteosarcoma by modulating of STAT3 and ROS/MAPK signalling pathways
por: Zuo, Dongqing, et al.
Publicado: (2016)

Effects of perturbations on the stability of equilibrium points in the CR3BP with luminous and heterogeneous spheroid primaries
por: Singh, Jagadish, et al.
Publicado: (2022)

The Ectopic Expression of SurvivinT34A and FilC Can Enhance the Oncolytic Effects of Vaccinia Virus in Murine Gastric Cancer
por: Wang, Minglong, et al.
Publicado: (2020)

Sorafenib and CuB exert synergistic antitumor effects against hepatocellular carcinoma cells via inhibition of STAT3 phosphorylation
por: Wang, Xiaoli, et al.
Publicado: (2020)

A novel genomic classification system of gastric cancer via integrating multidimensional genomic characteristics
por: Wang, Haiyong, et al.
Publicado: (2021)

MicroRNA-125b exerts antitumor functions in cutaneous squamous cell carcinoma by targeting the STAT3 pathway
por: Tian, Ke, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_jcjlhboic5dq66mvarc3irb7pq