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CK2-mediated CCDC106 phosphorylation is required for p53 degradation in cancer progression

BACKGROUND: Dysfunction of p53 is a key cause of cancer development, while CCDC106 can reduce p53 stability and is associated with lung cancer. However, the roles of CCDC106 in other cancer types and its upstream regulators have not been investigated. METHODS: The phosphorylation status was investig...

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Detalles Bibliográficos
Autores principales:	Ning, Yichong, Wang, Chunqing, Liu, Xin, Du, Yan, Liu, Shunlian, Liu, Kaili, Zhou, Jianlin, Zhou, Chang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423756/ https://www.ncbi.nlm.nih.gov/pubmed/30885251 http://dx.doi.org/10.1186/s13046-019-1137-8

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