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The small molecule Bcl-2/Mcl-1 inhibitor TW-37 shows single-agent cytotoxicity in neuroblastoma cell lines

BACKGROUND: High-risk neuroblastoma with N-Myc amplification remains a therapeutic challenge in paediatric oncology. Antagonism of pro-death Bcl-2 homology (BH) proteins to pro-survival BH members such as Mcl-1 and Bcl-2 has become a treatment approach, but previous studies suggest that a combined i...

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Detalles Bibliográficos
Autores principales:	Klenke, Stefanie, Akdeli, Neval, Stelmach, Patrick, Heukamp, Lukas, Schulte, Johannes H., Bachmann, Hagen S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423774/ https://www.ncbi.nlm.nih.gov/pubmed/30885150 http://dx.doi.org/10.1186/s12885-019-5439-1

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