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Loss of the TAM Receptor Axl Ameliorates Severe Zika Virus Pathogenesis and Reduces Apoptosis in Microglia
The TAM receptor, Axl, has been implicated as a candidate entry receptor for Zika virus (ZIKV) infection but has been shown as inessential for virus infection in mice. To probe the role of Axl in murine ZIKV infection, we developed a mouse model lacking the Axl receptor and the interferon alpha/beta...
Autores principales: | Hastings, Andrew K., Hastings, Katherine, Uraki, Ryuta, Hwang, Jesse, Gaitsch, Hallie, Dhaliwal, Khushwant, Williamson, Eric, Fikrig, Erol |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424058/ https://www.ncbi.nlm.nih.gov/pubmed/30884311 http://dx.doi.org/10.1016/j.isci.2019.03.003 |
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