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Primary pulmonary plasmacytoma presenting with rare IgG lambda monoclonal gammopathy

Extramedullaryplasmacytoma (EMP) represents a peculiar and typically progressive malignancy that can originate outside the bone marrow. Primary pulmonary plasmacytoma (PPP) is a rare subset of EMP, confined to the lung. A 55-year-old man, diabetic, non-smoker presented to our clinic with a right che...

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Autores principales: Rahim, Yasmin, Tareen, Farrukh Zia, Ahmed, Rashida, Khan, Javaid Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424279/
https://www.ncbi.nlm.nih.gov/pubmed/30846451
http://dx.doi.org/10.1136/bcr-2018-227514
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author Rahim, Yasmin
Tareen, Farrukh Zia
Ahmed, Rashida
Khan, Javaid Ahmed
author_facet Rahim, Yasmin
Tareen, Farrukh Zia
Ahmed, Rashida
Khan, Javaid Ahmed
author_sort Rahim, Yasmin
collection PubMed
description Extramedullaryplasmacytoma (EMP) represents a peculiar and typically progressive malignancy that can originate outside the bone marrow. Primary pulmonary plasmacytoma (PPP) is a rare subset of EMP, confined to the lung. A 55-year-old man, diabetic, non-smoker presented to our clinic with a right chest wall swelling. A routine chest radiograph showed a well-circumscribed opacity in the right upper lung zone. A CT of the chest revealed a large right upper lobe mass with extensive local infiltration. Biopsy and immunohistochemical evaluation led to a diagnosis of PPP. Screening for multiple myeloma was negative. Serum immunofixation showed an IgG lambda monoclonal gammopathy, found in a minority of PPP patients. In view of disease extent, treatment with chemotherapy and radiotherapy was initiated. The patient is currently in out patient follow-up and has shown a favourable response to the treatment with a considerable decrease in serum IgG levels.
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spelling pubmed-64242792019-04-05 Primary pulmonary plasmacytoma presenting with rare IgG lambda monoclonal gammopathy Rahim, Yasmin Tareen, Farrukh Zia Ahmed, Rashida Khan, Javaid Ahmed BMJ Case Rep Rare Disease Extramedullaryplasmacytoma (EMP) represents a peculiar and typically progressive malignancy that can originate outside the bone marrow. Primary pulmonary plasmacytoma (PPP) is a rare subset of EMP, confined to the lung. A 55-year-old man, diabetic, non-smoker presented to our clinic with a right chest wall swelling. A routine chest radiograph showed a well-circumscribed opacity in the right upper lung zone. A CT of the chest revealed a large right upper lobe mass with extensive local infiltration. Biopsy and immunohistochemical evaluation led to a diagnosis of PPP. Screening for multiple myeloma was negative. Serum immunofixation showed an IgG lambda monoclonal gammopathy, found in a minority of PPP patients. In view of disease extent, treatment with chemotherapy and radiotherapy was initiated. The patient is currently in out patient follow-up and has shown a favourable response to the treatment with a considerable decrease in serum IgG levels. BMJ Publishing Group 2019-03-06 /pmc/articles/PMC6424279/ /pubmed/30846451 http://dx.doi.org/10.1136/bcr-2018-227514 Text en © BMJ Publishing Group Limited 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Rare Disease
Rahim, Yasmin
Tareen, Farrukh Zia
Ahmed, Rashida
Khan, Javaid Ahmed
Primary pulmonary plasmacytoma presenting with rare IgG lambda monoclonal gammopathy
title Primary pulmonary plasmacytoma presenting with rare IgG lambda monoclonal gammopathy
title_full Primary pulmonary plasmacytoma presenting with rare IgG lambda monoclonal gammopathy
title_fullStr Primary pulmonary plasmacytoma presenting with rare IgG lambda monoclonal gammopathy
title_full_unstemmed Primary pulmonary plasmacytoma presenting with rare IgG lambda monoclonal gammopathy
title_short Primary pulmonary plasmacytoma presenting with rare IgG lambda monoclonal gammopathy
title_sort primary pulmonary plasmacytoma presenting with rare igg lambda monoclonal gammopathy
topic Rare Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424279/
https://www.ncbi.nlm.nih.gov/pubmed/30846451
http://dx.doi.org/10.1136/bcr-2018-227514
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