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Predicting mutations deleterious to function in beta-lactamase TEM1 using MM-GBSA
Missense mutations can have disastrous effects on the function of a protein. And as a result, they have been implicated in numerous diseases. However, the majority of missense variants only have a nominal impact on protein function. Thus, the ability to distinguish these two classes of missense muta...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424398/ https://www.ncbi.nlm.nih.gov/pubmed/30889230 http://dx.doi.org/10.1371/journal.pone.0214015 |