Cargando…

Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals

Control of arbovirus transmission remains focused on vector control through application of insecticides directly to the environment. However, these insecticide applications are often reactive interventions that can be poorly-targeted, inadequate for localized control during outbreaks, and opposed du...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Chilinh, Gray, Meg, Burton, Timothy A., Foy, Soleil L., Foster, John R., Gendernalik, Alex Lazr, Rückert, Claudia, Alout, Haoues, Young, Michael C., Boze, Broox, Ebel, Gregory D., Clapsaddle, Brady, Foy, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424467/
https://www.ncbi.nlm.nih.gov/pubmed/30845250
http://dx.doi.org/10.1371/journal.pntd.0007210
_version_ 1783404688566124544
author Nguyen, Chilinh
Gray, Meg
Burton, Timothy A.
Foy, Soleil L.
Foster, John R.
Gendernalik, Alex Lazr
Rückert, Claudia
Alout, Haoues
Young, Michael C.
Boze, Broox
Ebel, Gregory D.
Clapsaddle, Brady
Foy, Brian D.
author_facet Nguyen, Chilinh
Gray, Meg
Burton, Timothy A.
Foy, Soleil L.
Foster, John R.
Gendernalik, Alex Lazr
Rückert, Claudia
Alout, Haoues
Young, Michael C.
Boze, Broox
Ebel, Gregory D.
Clapsaddle, Brady
Foy, Brian D.
author_sort Nguyen, Chilinh
collection PubMed
description Control of arbovirus transmission remains focused on vector control through application of insecticides directly to the environment. However, these insecticide applications are often reactive interventions that can be poorly-targeted, inadequate for localized control during outbreaks, and opposed due to environmental and toxicity concerns. In this study, we developed endectocide-treated feed as a systemic endectocide for birds to target blood feeding Culex tarsalis, the primary West Nile virus (WNV) bridge vector in the western United States, and conducted preliminary tests on the effects of deploying this feed in the field. In lab tests, ivermectin (IVM) was the most effective endectocide tested against Cx. tarsalis and WNV-infection did not influence mosquito mortality from IVM. Chickens and wild Eurasian collared doves exhibited no signs of toxicity when fed solely on bird feed treated with concentrations up to 200 mg IVM/kg of diet, and significantly more Cx. tarsalis that blood fed on these birds died (greater than 80% mortality) compared to controls (less than 25% mortality). Mosquito mortality following blood feeding correlated with IVM serum concentrations at the time of blood feeding, which dropped rapidly after the withdrawal of treated feed. Preliminary field testing over one WNV season in Fort Collins, Colorado demonstrated that nearly all birds captured around treated bird feeders had detectable levels of IVM in their blood. However, entomological data showed that WNV transmission was non-significantly reduced around treated bird feeders. With further development, deployment of ivermectin-treated bird feed might be an effective, localized WNV transmission control tool.
format Online
Article
Text
id pubmed-6424467
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-64244672019-04-01 Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals Nguyen, Chilinh Gray, Meg Burton, Timothy A. Foy, Soleil L. Foster, John R. Gendernalik, Alex Lazr Rückert, Claudia Alout, Haoues Young, Michael C. Boze, Broox Ebel, Gregory D. Clapsaddle, Brady Foy, Brian D. PLoS Negl Trop Dis Research Article Control of arbovirus transmission remains focused on vector control through application of insecticides directly to the environment. However, these insecticide applications are often reactive interventions that can be poorly-targeted, inadequate for localized control during outbreaks, and opposed due to environmental and toxicity concerns. In this study, we developed endectocide-treated feed as a systemic endectocide for birds to target blood feeding Culex tarsalis, the primary West Nile virus (WNV) bridge vector in the western United States, and conducted preliminary tests on the effects of deploying this feed in the field. In lab tests, ivermectin (IVM) was the most effective endectocide tested against Cx. tarsalis and WNV-infection did not influence mosquito mortality from IVM. Chickens and wild Eurasian collared doves exhibited no signs of toxicity when fed solely on bird feed treated with concentrations up to 200 mg IVM/kg of diet, and significantly more Cx. tarsalis that blood fed on these birds died (greater than 80% mortality) compared to controls (less than 25% mortality). Mosquito mortality following blood feeding correlated with IVM serum concentrations at the time of blood feeding, which dropped rapidly after the withdrawal of treated feed. Preliminary field testing over one WNV season in Fort Collins, Colorado demonstrated that nearly all birds captured around treated bird feeders had detectable levels of IVM in their blood. However, entomological data showed that WNV transmission was non-significantly reduced around treated bird feeders. With further development, deployment of ivermectin-treated bird feed might be an effective, localized WNV transmission control tool. Public Library of Science 2019-03-07 /pmc/articles/PMC6424467/ /pubmed/30845250 http://dx.doi.org/10.1371/journal.pntd.0007210 Text en © 2019 Nguyen et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nguyen, Chilinh
Gray, Meg
Burton, Timothy A.
Foy, Soleil L.
Foster, John R.
Gendernalik, Alex Lazr
Rückert, Claudia
Alout, Haoues
Young, Michael C.
Boze, Broox
Ebel, Gregory D.
Clapsaddle, Brady
Foy, Brian D.
Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals
title Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals
title_full Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals
title_fullStr Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals
title_full_unstemmed Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals
title_short Evaluation of a novel West Nile virus transmission control strategy that targets Culex tarsalis with endectocide-containing blood meals
title_sort evaluation of a novel west nile virus transmission control strategy that targets culex tarsalis with endectocide-containing blood meals
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424467/
https://www.ncbi.nlm.nih.gov/pubmed/30845250
http://dx.doi.org/10.1371/journal.pntd.0007210
work_keys_str_mv AT nguyenchilinh evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals
AT graymeg evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals
AT burtontimothya evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals
AT foysoleill evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals
AT fosterjohnr evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals
AT gendernalikalexlazr evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals
AT ruckertclaudia evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals
AT alouthaoues evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals
AT youngmichaelc evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals
AT bozebroox evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals
AT ebelgregoryd evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals
AT clapsaddlebrady evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals
AT foybriand evaluationofanovelwestnilevirustransmissioncontrolstrategythattargetsculextarsaliswithendectocidecontainingbloodmeals