Metformin-associated Severe Lactic Acidosis in the Setting of Acute Kidney Injury

Metformin is a first-line biguanide agent for the treatment of diabetes mellitus. It has been known to be associated with lactic acidosis. This side effect especially worsens when being used with other medications affecting the kidney such as angiotensin-converting enzyme inhibitors (ACEi) and loop...

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Detalles Bibliográficos
Autores principales: Iftikhar, Hassaan, Saleem, Maryam, Kaji, Anand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424540/
https://www.ncbi.nlm.nih.gov/pubmed/30911453
http://dx.doi.org/10.7759/cureus.3897
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author Iftikhar, Hassaan
Saleem, Maryam
Kaji, Anand
author_facet Iftikhar, Hassaan
Saleem, Maryam
Kaji, Anand
author_sort Iftikhar, Hassaan
collection PubMed
description Metformin is a first-line biguanide agent for the treatment of diabetes mellitus. It has been known to be associated with lactic acidosis. This side effect especially worsens when being used with other medications affecting the kidney such as angiotensin-converting enzyme inhibitors (ACEi) and loop diuretics. This is a case of a 63-year-old male who suffered from metformin-induced lactic acidosis and underwent hemodialysis for treatment.
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spelling pubmed-64245402019-03-25 Metformin-associated Severe Lactic Acidosis in the Setting of Acute Kidney Injury Iftikhar, Hassaan Saleem, Maryam Kaji, Anand Cureus Internal Medicine Metformin is a first-line biguanide agent for the treatment of diabetes mellitus. It has been known to be associated with lactic acidosis. This side effect especially worsens when being used with other medications affecting the kidney such as angiotensin-converting enzyme inhibitors (ACEi) and loop diuretics. This is a case of a 63-year-old male who suffered from metformin-induced lactic acidosis and underwent hemodialysis for treatment. Cureus 2019-01-16 /pmc/articles/PMC6424540/ /pubmed/30911453 http://dx.doi.org/10.7759/cureus.3897 Text en Copyright © 2019, Iftikhar et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Iftikhar, Hassaan
Saleem, Maryam
Kaji, Anand
Metformin-associated Severe Lactic Acidosis in the Setting of Acute Kidney Injury
title Metformin-associated Severe Lactic Acidosis in the Setting of Acute Kidney Injury
title_full Metformin-associated Severe Lactic Acidosis in the Setting of Acute Kidney Injury
title_fullStr Metformin-associated Severe Lactic Acidosis in the Setting of Acute Kidney Injury
title_full_unstemmed Metformin-associated Severe Lactic Acidosis in the Setting of Acute Kidney Injury
title_short Metformin-associated Severe Lactic Acidosis in the Setting of Acute Kidney Injury
title_sort metformin-associated severe lactic acidosis in the setting of acute kidney injury
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424540/
https://www.ncbi.nlm.nih.gov/pubmed/30911453
http://dx.doi.org/10.7759/cureus.3897
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AT kajianand metforminassociatedseverelacticacidosisinthesettingofacutekidneyinjury

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