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Automated cryo-EM structure refinement using correlation-driven molecular dynamics

We present a correlation-driven molecular dynamics (CDMD) method for automated refinement of atomistic models into cryo-electron microscopy (cryo-EM) maps at resolutions ranging from near-atomic to subnanometer. It utilizes a chemically accurate force field and thermodynamic sampling to improve the...

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Detalles Bibliográficos
Autores principales:	Igaev, Maxim, Kutzner, Carsten, Bock, Lars V, Vaiana, Andrea C, Grubmüller, Helmut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424565/ https://www.ncbi.nlm.nih.gov/pubmed/30829573 http://dx.doi.org/10.7554/eLife.43542

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