Defining the Functional Role of Na(V)1.7 in Human Nociception

Loss-of-function mutations in Na(V)1.7 cause congenital insensitivity to pain (CIP); this voltage-gated sodium channel is therefore a key target for analgesic drug development. Utilizing a multi-modal approach, we investigated how Na(V)1.7 mutations lead to human pain insensitivity. Skin biopsy and...

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Detalles Bibliográficos
Autores principales: McDermott, Lucy A., Weir, Greg A., Themistocleous, Andreas C., Segerdahl, Andrew R., Blesneac, Iulia, Baskozos, Georgios, Clark, Alex J., Millar, Val, Peck, Liam J., Ebner, Daniel, Tracey, Irene, Serra, Jordi, Bennett, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424805/
https://www.ncbi.nlm.nih.gov/pubmed/30795902
http://dx.doi.org/10.1016/j.neuron.2019.01.047

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