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Hepatocellular Carcinoma: Texture Analysis of Preoperative Computed Tomography Images Can Provide Markers of Tumor Grade and Disease-Free Survival

OBJECTIVE: To investigate the usefulness of computed tomography (CT) texture analysis (CTTA) in estimating histologic tumor grade and in predicting disease-free survival (DFS) after surgical resection in patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Eighty-one patients with a...

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Autores principales: Oh, Jiseon, Lee, Jeong Min, Park, Junghoan, Joo, Ijin, Yoon, Jeong Hee, Lee, Dong Ho, Ganeshan, Balaji, Han, Joon Koo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Radiology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424831/
https://www.ncbi.nlm.nih.gov/pubmed/30887739
http://dx.doi.org/10.3348/kjr.2018.0501
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author Oh, Jiseon
Lee, Jeong Min
Park, Junghoan
Joo, Ijin
Yoon, Jeong Hee
Lee, Dong Ho
Ganeshan, Balaji
Han, Joon Koo
author_facet Oh, Jiseon
Lee, Jeong Min
Park, Junghoan
Joo, Ijin
Yoon, Jeong Hee
Lee, Dong Ho
Ganeshan, Balaji
Han, Joon Koo
author_sort Oh, Jiseon
collection PubMed
description OBJECTIVE: To investigate the usefulness of computed tomography (CT) texture analysis (CTTA) in estimating histologic tumor grade and in predicting disease-free survival (DFS) after surgical resection in patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Eighty-one patients with a single HCC who had undergone quadriphasic liver CT followed by surgical resection were enrolled. Texture analysis of tumors on preoperative CT images was performed using commercially available software. The mean, mean of positive pixels (MPP), entropy, kurtosis, skewness, and standard deviation (SD) of the pixel distribution histogram were derived with and without filtration. The texture features were then compared between groups classified according to histologic grade. Kaplan-Meier and Cox proportional hazards analyses were performed to determine the relationship between texture features and DFS. RESULTS: SD and MPP quantified from fine to coarse textures on arterial-phase CT images showed significant positive associations with the histologic grade of HCC (p < 0.05). Kaplan-Meier analysis identified most CT texture features across the different filters from fine to coarse texture scales as significant univariate markers of DFS. Cox proportional hazards analysis identified skewness on arterial-phase images (fine texture scale, spatial scaling factor [SSF] 2.0, p < 0.001; medium texture scale, SSF 3.0, p < 0.001), tumor size (p = 0.001), microscopic vascular invasion (p = 0.034), rim arterial enhancement (p = 0.024), and peritumoral parenchymal enhancement (p = 0.010) as independent predictors of DFS. CONCLUSION: CTTA was demonstrated to provide texture features significantly correlated with higher tumor grade as well as predictive markers of DFS after surgical resection of HCCs in addition to other valuable imaging and clinico-pathologic parameters.
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spelling pubmed-64248312019-04-01 Hepatocellular Carcinoma: Texture Analysis of Preoperative Computed Tomography Images Can Provide Markers of Tumor Grade and Disease-Free Survival Oh, Jiseon Lee, Jeong Min Park, Junghoan Joo, Ijin Yoon, Jeong Hee Lee, Dong Ho Ganeshan, Balaji Han, Joon Koo Korean J Radiol Gastrointestinal Imaging OBJECTIVE: To investigate the usefulness of computed tomography (CT) texture analysis (CTTA) in estimating histologic tumor grade and in predicting disease-free survival (DFS) after surgical resection in patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Eighty-one patients with a single HCC who had undergone quadriphasic liver CT followed by surgical resection were enrolled. Texture analysis of tumors on preoperative CT images was performed using commercially available software. The mean, mean of positive pixels (MPP), entropy, kurtosis, skewness, and standard deviation (SD) of the pixel distribution histogram were derived with and without filtration. The texture features were then compared between groups classified according to histologic grade. Kaplan-Meier and Cox proportional hazards analyses were performed to determine the relationship between texture features and DFS. RESULTS: SD and MPP quantified from fine to coarse textures on arterial-phase CT images showed significant positive associations with the histologic grade of HCC (p < 0.05). Kaplan-Meier analysis identified most CT texture features across the different filters from fine to coarse texture scales as significant univariate markers of DFS. Cox proportional hazards analysis identified skewness on arterial-phase images (fine texture scale, spatial scaling factor [SSF] 2.0, p < 0.001; medium texture scale, SSF 3.0, p < 0.001), tumor size (p = 0.001), microscopic vascular invasion (p = 0.034), rim arterial enhancement (p = 0.024), and peritumoral parenchymal enhancement (p = 0.010) as independent predictors of DFS. CONCLUSION: CTTA was demonstrated to provide texture features significantly correlated with higher tumor grade as well as predictive markers of DFS after surgical resection of HCCs in addition to other valuable imaging and clinico-pathologic parameters. The Korean Society of Radiology 2019-04 2019-02-25 /pmc/articles/PMC6424831/ /pubmed/30887739 http://dx.doi.org/10.3348/kjr.2018.0501 Text en Copyright © 2019 The Korean Society of Radiology http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Gastrointestinal Imaging
Oh, Jiseon
Lee, Jeong Min
Park, Junghoan
Joo, Ijin
Yoon, Jeong Hee
Lee, Dong Ho
Ganeshan, Balaji
Han, Joon Koo
Hepatocellular Carcinoma: Texture Analysis of Preoperative Computed Tomography Images Can Provide Markers of Tumor Grade and Disease-Free Survival
title Hepatocellular Carcinoma: Texture Analysis of Preoperative Computed Tomography Images Can Provide Markers of Tumor Grade and Disease-Free Survival
title_full Hepatocellular Carcinoma: Texture Analysis of Preoperative Computed Tomography Images Can Provide Markers of Tumor Grade and Disease-Free Survival
title_fullStr Hepatocellular Carcinoma: Texture Analysis of Preoperative Computed Tomography Images Can Provide Markers of Tumor Grade and Disease-Free Survival
title_full_unstemmed Hepatocellular Carcinoma: Texture Analysis of Preoperative Computed Tomography Images Can Provide Markers of Tumor Grade and Disease-Free Survival
title_short Hepatocellular Carcinoma: Texture Analysis of Preoperative Computed Tomography Images Can Provide Markers of Tumor Grade and Disease-Free Survival
title_sort hepatocellular carcinoma: texture analysis of preoperative computed tomography images can provide markers of tumor grade and disease-free survival
topic Gastrointestinal Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424831/
https://www.ncbi.nlm.nih.gov/pubmed/30887739
http://dx.doi.org/10.3348/kjr.2018.0501
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