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Early Enzyme Replacement Therapy Improves Hearing and Immune Defects in Adenosine Deaminase Deficient-Mice

Background: Inherited defects in adenosine deaminase (ADA) cause severe immune deficiency, which can be corrected by ADA enzyme replacement therapy (ERT). Additionally, ADA-deficient patients suffer from hearing impairment. We hypothesized that ADA-deficient (–/–) mice also exhibit hearing abnormali...

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Detalles Bibliográficos
Autores principales:	Xu, Xiaobai, Negandhi, Jaina, Min, Weixian, Tsui, Michael, Post, Martin, Harrison, Robert V., Grunebaum, Eyal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424861/ https://www.ncbi.nlm.nih.gov/pubmed/30918508 http://dx.doi.org/10.3389/fimmu.2019.00416

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