The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia

New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological p...

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Autores principales: Ashton, Melanie M., Dean, Olivia M., Walker, Adam J., Bortolasci, Chiara C., Ng, Chee H., Hopwood, Malcolm, Harvey, Brian H., Möller, Marisa, McGrath, John J., Marx, Wolfgang, Turner, Alyna, Dodd, Seetal, Scott, James G., Khoo, Jon-Paul, Walder, Ken, Sarris, Jerome, Berk, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Psychiatry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424889/
https://www.ncbi.nlm.nih.gov/pubmed/30918489
http://dx.doi.org/10.3389/fpsyt.2019.00115
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author Ashton, Melanie M.
Dean, Olivia M.
Walker, Adam J.
Bortolasci, Chiara C.
Ng, Chee H.
Hopwood, Malcolm
Harvey, Brian H.
Möller, Marisa
McGrath, John J.
Marx, Wolfgang
Turner, Alyna
Dodd, Seetal
Scott, James G.
Khoo, Jon-Paul
Walder, Ken
Sarris, Jerome
Berk, Michael
author_facet Ashton, Melanie M.
Dean, Olivia M.
Walker, Adam J.
Bortolasci, Chiara C.
Ng, Chee H.
Hopwood, Malcolm
Harvey, Brian H.
Möller, Marisa
McGrath, John J.
Marx, Wolfgang
Turner, Alyna
Dodd, Seetal
Scott, James G.
Khoo, Jon-Paul
Walder, Ken
Sarris, Jerome
Berk, Michael
author_sort Ashton, Melanie M.
collection PubMed
description New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.
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spelling pubmed-64248892019-03-27 The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia Ashton, Melanie M. Dean, Olivia M. Walker, Adam J. Bortolasci, Chiara C. Ng, Chee H. Hopwood, Malcolm Harvey, Brian H. Möller, Marisa McGrath, John J. Marx, Wolfgang Turner, Alyna Dodd, Seetal Scott, James G. Khoo, Jon-Paul Walder, Ken Sarris, Jerome Berk, Michael Front Psychiatry Psychiatry New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders. Frontiers Media S.A. 2019-03-13 /pmc/articles/PMC6424889/ /pubmed/30918489 http://dx.doi.org/10.3389/fpsyt.2019.00115 Text en Copyright © 2019 Ashton, Dean, Walker, Bortolasci, Ng, Hopwood, Harvey, Möller, McGrath, Marx, Turner, Dodd, Scott, Khoo, Walder, Sarris and Berk. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Ashton, Melanie M.
Dean, Olivia M.
Walker, Adam J.
Bortolasci, Chiara C.
Ng, Chee H.
Hopwood, Malcolm
Harvey, Brian H.
Möller, Marisa
McGrath, John J.
Marx, Wolfgang
Turner, Alyna
Dodd, Seetal
Scott, James G.
Khoo, Jon-Paul
Walder, Ken
Sarris, Jerome
Berk, Michael
The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia
title The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia
title_full The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia
title_fullStr The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia
title_full_unstemmed The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia
title_short The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia
title_sort therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424889/
https://www.ncbi.nlm.nih.gov/pubmed/30918489
http://dx.doi.org/10.3389/fpsyt.2019.00115
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