Uncovering the Functional Link Between SHANK3 Deletions and Deficiency in Neurodevelopment Using iPSC-Derived Human Neurons

SHANK3 mutations, including de novo deletions, have been associated with autism spectrum disorders (ASD). However, the effects of SHANK3 loss of function on neurodevelopment remain poorly understood. Here we generated human induced pluripotent stem cells (iPSC) in vitro, followed by neuro-differenti...

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Detalles Bibliográficos
Autores principales: Huang, Guanqun, Chen, Shuting, Chen, Xiaoxia, Zheng, Jiajun, Xu, Zhuoran, Doostparast Torshizi, Abolfazl, Gong, Siyi, Chen, Qingpei, Ma, Xiaokuang, Yu, Jiandong, Zhou, Libing, Qiu, Shenfeng, Wang, Kai, Shi, Lingling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424902/
https://www.ncbi.nlm.nih.gov/pubmed/30918484
http://dx.doi.org/10.3389/fnana.2019.00023

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