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Serum Concentrations of Trace Elements Zinc, Copper, Selenium, and Manganese in Critically Ill Patients

We measured serum concentrations of trace elements and evaluated their clinical significance in relation to treatment outcomes of critically ill patients. A total of 167 participants (105 men and 62 women; average age, 61.4 years; age range, 18–90 years) were enrolled. Arterial blood concentrations...

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Autores principales: Lee, Yeon Hee, Bang, Eun-Sook, Lee, Ji-Hyun, Lee, Jung-Dong, Kang, Dae Ryong, Hong, Jeong, Lee, Jae-Myeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424942/
https://www.ncbi.nlm.nih.gov/pubmed/30047077
http://dx.doi.org/10.1007/s12011-018-1429-4
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author Lee, Yeon Hee
Bang, Eun-Sook
Lee, Ji-Hyun
Lee, Jung-Dong
Kang, Dae Ryong
Hong, Jeong
Lee, Jae-Myeong
author_facet Lee, Yeon Hee
Bang, Eun-Sook
Lee, Ji-Hyun
Lee, Jung-Dong
Kang, Dae Ryong
Hong, Jeong
Lee, Jae-Myeong
author_sort Lee, Yeon Hee
collection PubMed
description We measured serum concentrations of trace elements and evaluated their clinical significance in relation to treatment outcomes of critically ill patients. A total of 167 participants (105 men and 62 women; average age, 61.4 years; age range, 18–90 years) were enrolled. Arterial blood concentrations of the trace elements zinc, copper, selenium, and manganese were measured every 14 days. At the time of intensive care unit (ICU) admission, serum concentrations of zinc, selenium, copper, and manganese were lower than the normal values in 75.1, 1.8, 37.8, and 2.1% of patients, respectively. Serum trace element concentrations measured on day 14 of ICU stay were higher than those measured at the time of ICU admission for zinc (53.3 → 80.7 μg/L) and copper (87.1 → 102.3 μg/L). Increased serum zinc and copper concentrations during ICU care were associated with a significantly lower mortality compared to decreased concentrations of zinc (15.6 vs. 83.3%, p = 0.003) and copper (5.6 vs. 50.0%, p = 0.013). At the time of ICU admission, low serum levels of zinc and copper were observed. Patients with increased serum concentrations of zinc and copper had significantly lower mortality.
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spelling pubmed-64249422019-04-05 Serum Concentrations of Trace Elements Zinc, Copper, Selenium, and Manganese in Critically Ill Patients Lee, Yeon Hee Bang, Eun-Sook Lee, Ji-Hyun Lee, Jung-Dong Kang, Dae Ryong Hong, Jeong Lee, Jae-Myeong Biol Trace Elem Res Article We measured serum concentrations of trace elements and evaluated their clinical significance in relation to treatment outcomes of critically ill patients. A total of 167 participants (105 men and 62 women; average age, 61.4 years; age range, 18–90 years) were enrolled. Arterial blood concentrations of the trace elements zinc, copper, selenium, and manganese were measured every 14 days. At the time of intensive care unit (ICU) admission, serum concentrations of zinc, selenium, copper, and manganese were lower than the normal values in 75.1, 1.8, 37.8, and 2.1% of patients, respectively. Serum trace element concentrations measured on day 14 of ICU stay were higher than those measured at the time of ICU admission for zinc (53.3 → 80.7 μg/L) and copper (87.1 → 102.3 μg/L). Increased serum zinc and copper concentrations during ICU care were associated with a significantly lower mortality compared to decreased concentrations of zinc (15.6 vs. 83.3%, p = 0.003) and copper (5.6 vs. 50.0%, p = 0.013). At the time of ICU admission, low serum levels of zinc and copper were observed. Patients with increased serum concentrations of zinc and copper had significantly lower mortality. Springer US 2018-07-25 2019 /pmc/articles/PMC6424942/ /pubmed/30047077 http://dx.doi.org/10.1007/s12011-018-1429-4 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Lee, Yeon Hee
Bang, Eun-Sook
Lee, Ji-Hyun
Lee, Jung-Dong
Kang, Dae Ryong
Hong, Jeong
Lee, Jae-Myeong
Serum Concentrations of Trace Elements Zinc, Copper, Selenium, and Manganese in Critically Ill Patients
title Serum Concentrations of Trace Elements Zinc, Copper, Selenium, and Manganese in Critically Ill Patients
title_full Serum Concentrations of Trace Elements Zinc, Copper, Selenium, and Manganese in Critically Ill Patients
title_fullStr Serum Concentrations of Trace Elements Zinc, Copper, Selenium, and Manganese in Critically Ill Patients
title_full_unstemmed Serum Concentrations of Trace Elements Zinc, Copper, Selenium, and Manganese in Critically Ill Patients
title_short Serum Concentrations of Trace Elements Zinc, Copper, Selenium, and Manganese in Critically Ill Patients
title_sort serum concentrations of trace elements zinc, copper, selenium, and manganese in critically ill patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424942/
https://www.ncbi.nlm.nih.gov/pubmed/30047077
http://dx.doi.org/10.1007/s12011-018-1429-4
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