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Zebrafish as a model for kidney function and disease
Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the various kidney diseases and to screen for therapeut...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424945/ https://www.ncbi.nlm.nih.gov/pubmed/29502161 http://dx.doi.org/10.1007/s00467-018-3921-7 |
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author | Outtandy, Priya Russell, Claire Kleta, Robert Bockenhauer, Detlef |
author_facet | Outtandy, Priya Russell, Claire Kleta, Robert Bockenhauer, Detlef |
author_sort | Outtandy, Priya |
collection | PubMed |
description | Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the various kidney diseases and to screen for therapeutic compounds, but the use especially of mammalian models should be minimised in the interest of animal welfare. Zebrafish are increasingly used, as they are genetically tractable and have a basic renal anatomy comparable to mammalian kidneys with glomerular filtration and tubular filtration processing. Here, we discuss how zebrafish have advanced the study of nephrology and the mechanisms underlying kidney disease. |
format | Online Article Text |
id | pubmed-6424945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-64249452019-04-05 Zebrafish as a model for kidney function and disease Outtandy, Priya Russell, Claire Kleta, Robert Bockenhauer, Detlef Pediatr Nephrol Review Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the various kidney diseases and to screen for therapeutic compounds, but the use especially of mammalian models should be minimised in the interest of animal welfare. Zebrafish are increasingly used, as they are genetically tractable and have a basic renal anatomy comparable to mammalian kidneys with glomerular filtration and tubular filtration processing. Here, we discuss how zebrafish have advanced the study of nephrology and the mechanisms underlying kidney disease. Springer Berlin Heidelberg 2018-03-03 2019 /pmc/articles/PMC6424945/ /pubmed/29502161 http://dx.doi.org/10.1007/s00467-018-3921-7 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Outtandy, Priya Russell, Claire Kleta, Robert Bockenhauer, Detlef Zebrafish as a model for kidney function and disease |
title | Zebrafish as a model for kidney function and disease |
title_full | Zebrafish as a model for kidney function and disease |
title_fullStr | Zebrafish as a model for kidney function and disease |
title_full_unstemmed | Zebrafish as a model for kidney function and disease |
title_short | Zebrafish as a model for kidney function and disease |
title_sort | zebrafish as a model for kidney function and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424945/ https://www.ncbi.nlm.nih.gov/pubmed/29502161 http://dx.doi.org/10.1007/s00467-018-3921-7 |
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