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Zebrafish as a model for kidney function and disease

Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the various kidney diseases and to screen for therapeut...

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Detalles Bibliográficos
Autores principales: Outtandy, Priya, Russell, Claire, Kleta, Robert, Bockenhauer, Detlef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424945/
https://www.ncbi.nlm.nih.gov/pubmed/29502161
http://dx.doi.org/10.1007/s00467-018-3921-7
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author Outtandy, Priya
Russell, Claire
Kleta, Robert
Bockenhauer, Detlef
author_facet Outtandy, Priya
Russell, Claire
Kleta, Robert
Bockenhauer, Detlef
author_sort Outtandy, Priya
collection PubMed
description Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the various kidney diseases and to screen for therapeutic compounds, but the use especially of mammalian models should be minimised in the interest of animal welfare. Zebrafish are increasingly used, as they are genetically tractable and have a basic renal anatomy comparable to mammalian kidneys with glomerular filtration and tubular filtration processing. Here, we discuss how zebrafish have advanced the study of nephrology and the mechanisms underlying kidney disease.
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spelling pubmed-64249452019-04-05 Zebrafish as a model for kidney function and disease Outtandy, Priya Russell, Claire Kleta, Robert Bockenhauer, Detlef Pediatr Nephrol Review Kidney disease is a global problem with around three million people diagnosed in the UK alone and the incidence is rising. Research is critical to develop better treatments. Animal models can help to better understand the pathophysiology behind the various kidney diseases and to screen for therapeutic compounds, but the use especially of mammalian models should be minimised in the interest of animal welfare. Zebrafish are increasingly used, as they are genetically tractable and have a basic renal anatomy comparable to mammalian kidneys with glomerular filtration and tubular filtration processing. Here, we discuss how zebrafish have advanced the study of nephrology and the mechanisms underlying kidney disease. Springer Berlin Heidelberg 2018-03-03 2019 /pmc/articles/PMC6424945/ /pubmed/29502161 http://dx.doi.org/10.1007/s00467-018-3921-7 Text en © The Author(s) 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Outtandy, Priya
Russell, Claire
Kleta, Robert
Bockenhauer, Detlef
Zebrafish as a model for kidney function and disease
title Zebrafish as a model for kidney function and disease
title_full Zebrafish as a model for kidney function and disease
title_fullStr Zebrafish as a model for kidney function and disease
title_full_unstemmed Zebrafish as a model for kidney function and disease
title_short Zebrafish as a model for kidney function and disease
title_sort zebrafish as a model for kidney function and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424945/
https://www.ncbi.nlm.nih.gov/pubmed/29502161
http://dx.doi.org/10.1007/s00467-018-3921-7
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